Electroneutral sodium bicarbonate exchanger 1

SLC4A8
Identifiers
Aliases	SLC4A8, NBC3, NDCBE, solute carrier family 4 member 8
External IDs	OMIM: 605024 MGI: 1928745 HomoloGene: 68419 GeneCards: SLC4A8
Gene location (Human)
Chr.	Chromosome 12 (human)
End	51,515,763 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	100,721,849 bp
RNA expression pattern
	Top expressed in
	pons; ; Brodmann area 23; ; superior vestibular nucleus; ; corpus callosum; ; middle temporal gyrus; ; ventral tegmental area; ; postcentral gyrus; ; inferior ganglion of vagus nerve; ; cerebellar vermis; ; subthalamic nucleus;
	Top expressed in
	spermatocyte; ; spermatid; ; secondary oocyte; ; superior frontal gyrus; ; cerebellar cortex; ; medial vestibular nucleus; ; seminal vesicula; ; lateral geniculate nucleus; ; ventromedial nucleus; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antiporter activity; inorganic anion exchanger activity; anion transmembrane transporter activity; sodium:bicarbonate symporter activity;
Cellular component	integral component of membrane; neuronal cell body membrane; neuron projection; plasma membrane; membrane; integral component of plasma membrane;
Biological process	anion transport; sodium ion transport; regulation of intracellular pH; inorganic anion transport; ion transport; bicarbonate transport; transmembrane transport; anion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9498
	59033
	ENSG00000050438
	ENSMUSG00000023032
	Q2Y0W8
	Q8JZR6
NM_001039960; NM_001258401; NM_001258402; NM_001258403; NM_001267615;
	NM_004858; NM_001405266; NM_001405268; NM_001405270
	NM_001033218; NM_021530; NM_001347102
	NP_001035049; NP_001245330; NP_001245331; NP_001245332; NP_001254544
	NP_001334031; NP_067505
	Wikidata
View/Edit Human	View/Edit Mouse

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.^[5]^[6]

Interactions

SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1^[7]^[8] and Cystic fibrosis transmembrane conductance regulator.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000050438 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023032 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na⁺-driven Cl⁻HCO₃ exchanger". J Biol Chem. 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997.
↑ "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8".
↑ Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (March 2003). "The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. S2CID 7070088.
1 2 Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.

Soleimani M (2002). "Na⁺:HCO₃⁻ cs (NBC): expression and regulation in the kidney". J. Nephrol. 15 (Suppl 5): S32–40. PMID 12027220.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na⁺/HCO₃⁻ cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710.
Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (2003). "The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. S2CID 7070088.
Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.
Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC, Aalkjaer C, Nielsen S (2002). "Immunolocalization of electroneutral Na⁺-HCO cotransporters in human and rat salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2): G473–80. doi:10.1152/ajpgi.00421.2001. PMID 12121896.
Amlal H, Burnham CE, Soleimani M (1999). "Characterization of Na⁺/HCO₃⁻ cotransporter isoform NBC-3". Am. J. Physiol. 276 (6 Pt 2): F903–13. doi:10.1152/ajprenal.1999.276.6.F903. PMID 10362779.
Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000050438 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023032 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11133997-5] Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na⁺-driven Cl⁻HCO₃ exchanger". J Biol Chem. 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997.

[entrez-6] "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8".

[pmid12444018-7] Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (March 2003). "The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. S2CID 7070088.

[pmid12403779-8] 1 2 Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.

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See also

Interactions

References

Further reading