SPSB1

SPSB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JK9, 3F2O
Identifiers
Aliases	SPSB1, SSB-1, SSB1, splA/ryanodine receptor domain and SOCS box containing 1
External IDs	OMIM: 611657 MGI: 1921896 HomoloGene: 11832 GeneCards: SPSB1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	9,369,532 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	150,039,500 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; gastric mucosa; ; saphenous vein; ; gallbladder; ; vena cava; ; right coronary artery; ; left coronary artery; ; gastrocnemius muscle; ; subcutaneous adipose tissue; ; islet of Langerhans;
	Top expressed in
	cumulus cell; ; molar; ; ascending aorta; ; aortic valve; ; ankle; ; extraocular muscle; ; subcutaneous adipose tissue; ; brown adipose tissue; ; iris; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity; ubiquitin ligase-substrate adaptor activity;
Cellular component	cytoplasm; cytosol; SCF ubiquitin ligase complex;
Biological process	protein ubiquitination; protein polyubiquitination; post-translational protein modification; ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	80176
	74646
	ENSG00000171621
	ENSMUSG00000039911
	Q96BD6
	Q9D5L7
	NM_025106
	NM_029035
	NP_079382
	NP_083311
	Wikidata
View/Edit Human	View/Edit Mouse

SPRY domain-containing SOCS box protein 1 is a protein that in humans is encoded by the SPSB1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171621 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039911 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang D, Li Z, Messing EM, Wu G (Apr 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". J Biol Chem. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.
↑ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
↑ "Entrez Gene: SPSB1 splA/ryanodine receptor domain and SOCS box containing 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171621 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039911 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15713673-5] Wang D, Li Z, Messing EM, Wu G (Apr 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". J Biol Chem. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.

[pmid12076535-6] Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.

[entrez-7] "Entrez Gene: SPSB1 splA/ryanodine receptor domain and SOCS box containing 1".

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[4]

[5]

[6]

[7]

References

Further reading