SUPT5H
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSUPT5H, SPT5, SPT5H, Tat-CT1, SPT5 homolog, DSIF elongation factor subunit
External IDsOMIM: 602102 MGI: 1202400 HomoloGene: 2384 GeneCards: SUPT5H
Orthologs
SpeciesHumanMouse
Entrez

6829

20924

Ensembl

ENSG00000196235

ENSMUSG00000003435

UniProt

O00267

O55201

RefSeq (mRNA)

NM_013676

RefSeq (protein)

NP_038704

Location (UCSC)Chr 19: 39.44 – 39.48 MbChr 7: 28.01 – 28.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.[5][6]

Interactions

SUPT5H has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196235 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003435 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chiang PW, Fogel E, Jackson CL, Lieuallen K, Lennon G, Qu X, Wang SQ, Kurnit DM (Dec 1996). "Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5". Genomics. 38 (3): 421–4. doi:10.1006/geno.1996.0646. PMID 8975720.
  6. "Entrez Gene: SUPT5H Suppressor of Ty 5 homolog (S. cerevisiae)".
  7. 1 2 Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (Sep 2000). "CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA". Molecular and Cellular Biology. 20 (18): 6958–69. doi:10.1128/mcb.20.18.6958-6969.2000. PMC 88771. PMID 10958691.
  8. 1 2 Kim JB, Yamaguchi Y, Wada T, Handa H, Sharp PA (Sep 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Molecular and Cellular Biology. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. PMC 84462. PMID 10454543.
  9. Lavoie SB, Albert AL, Handa H, Vincent M, Bensaude O (Sep 2001). "The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9". Journal of Molecular Biology. 312 (4): 675–85. doi:10.1006/jmbi.2001.4991. PMID 11575923.
  10. Wada T, Takagi T, Yamaguchi Y, Ferdous A, Imai T, Hirose S, Sugimoto S, Yano K, Hartzog GA, Winston F, Buratowski S, Handa H (Feb 1998). "DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs". Genes & Development. 12 (3): 343–56. doi:10.1101/gad.12.3.343. PMC 316480. PMID 9450929.
  11. 1 2 Kwak YT, Guo J, Prajapati S, Park KJ, Surabhi RM, Miller B, Gehrig P, Gaynor RB (Apr 2003). "Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties". Molecular Cell. 11 (4): 1055–66. doi:10.1016/s1097-2765(03)00101-1. PMID 12718890.

Further reading

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