Scott D. Tanner Scientist

Scott Tanner is a Canadian scientist, inventor,[1][2] and entrepreneur.[3] His areas of expertise include mass spectroscopy, especially inductively coupled plasma mass spectrometry (ICP-MS), and mass cytometry.

Scott is best known for his work on the fundamentals of Inductively Coupled Plasma Mass Spectrometry,[4] for the invention of mass cytometry,[5] and co-founding (with Dmitry Bandura, Vladimir Baranov and Olga Ornatsky) DVS Sciences[3] in 2004,(acquired by Fluidigm in 2014 and then renamed to Standard BioTools in 2022[6]) the company that first commercialized the instrument and reagents of mass cytometry.

Early life and education

Scott was born and raised in St. Catharines, Ontario Canada. He bought his first chemistry set, from his brother, at age 6.[7][8] Through his early teenage years, he was provided with laboratory space at Brock University, under the guidance of Dr. E.A. Cherniak and Dr. F.P. Koffyberg, where he attempted to replicate Geiger–Marsden experiments also known as Rutherford’s experiment (scattering of alpha particles by gold foil) using various home-built instruments, including cloud chambers.[7][8]

Scott graduated with a BSC in Chemistry from York University in 1976. During his undergraduate years, he became a nationally ranked gymnast.[7][8][9] An injury at the Olympic trials ended his competitive gymnastics career, and he took up marathon running during graduate school (best time 2:47:13).[7][8] He received a Doctor of Philosophy (Chemistry) from York University in 1980, having studied ion-molecule reaction kinetics and flame ion chemistry with Drs. D.K Bohme and J.M. Goodings.[7][8]

Biography

Dr. Tanner joined SCIEX, which later became MDS SCIEX, in 1980 as a research scientist. He became Principal Scientist in 2000. In his 25 years at SCIEX, Dr. Tanner developed and helped to commercialize a string of Mass Spectrometry products.

Scott published over 74 peer-reviewed scientific articles, and holds 22 US patents[10] (with corresponding filings in other countries), including 13 patents on Mass Cytometry technology

Scott was a co-founder of DVS Sciences and, as the President and CEO, saw the company through the development and commercial launch of its first products.

The products that DVS Sciences brought to the global market were originally developed at the University of Toronto where Dr. Tanner was a Professor in the Institute of Biomaterials and Biomedical Engineering and then in Chemistry.

Career

  • Principal Scientist SCIEX - 1980-2005[7]
  • Associate Professor (CLTA) at the University of Toronto, first in the Institute of Biomaterials and Biomedical Engineering (2005-2008) and then in Chemistry 2008-2013.
  • President DVS Sciences 2004[11] - 2015
    (acquired by Fluidigm in 2014)
  • Adjunct Professor at York University in the Department of Chemistry 2015-2018

Books

  • 2003 - Plasma Source Mass Spectrometry: Applications and Emerging Technologies ISBN 0854046038[12]
  • 2001 - Plasma Source Mass Spectrometry: The New Millennium ISBN 0854048952[13]
  • 1999 - Plasma Source Mass Spectrometry: New Developments and Applications ISBN 0854047492[14]
  • 1997 - Plasma Source Mass Spectrometry: Developments and Applications ISBN 0854047271[15]

Research

Awards and honors

Publications

Scott has published more than 75 peer-reviewed articles.
The 13 most cited (more than 200 citations each) include:

  • May 2011 - Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum[35] )
  • Sept 2010 - Highly Multiparametric Analysis by Mass Cytometry[36]
  • Aug 2009 - Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-Of-Flight Mass Spectrometry[37]
  • Sept 2002 - Reaction Cells and Collision Cells for ICP-MS: A Tutorial Review[38]
  • April 2002 - A Sensitive and Quantitative Element-Tagged Immunoassay with ICPMS Detection[39]
  • April 2002 - Detection of Ultratrace Phosphorus and Sulfur by Quadrupole ICPMS with Dynamic Reaction Cell[40]
  • July 2001 - Reaction Chemistry and Collisional Processes in Multipole Devices for Resolving Isobaric Interferences in ICP–MS[41]
  • Aug 2000 - A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). Part III.[42]
  • Nov 1999 - A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). Part II. Reduction of Interferences Pproduced within the Cell[43]
  • March 1999 - Theory, Design, and Operation of a Dynamic Reaction Cell for ICP-MS[44]
  • Jan 1995 - Characterization of Ionization and Matrix Suppression in Inductively Coupled ‘Cold’ Plasma Mass Spectrometry[45]
  • June 1992 - Space Charge in ICP-MS: Calculation and Implications[46]
  • July 1988 - Nonspectroscopic Interelement Interferences in Inductively Coupled Plasma Mass Spectrometry[47]

A more complete listing of his publications can be found on Google Scholar

References

  1. ↑ "Patents by Inventor Scott D. Tanner". Justia.com.
  2. ↑ "Scott D. Taner Inventions". Patentguru.com.
  3. 1 2 "Co-Founder of DVS Sciences". MaRSdd.com. 2011.
  4. ↑ D. J. Douglas; S.D. Tanner (1998). "Fundamental Considerations in ICP-MS". In Montaser, Akbar (ed.). Inductively Coupled Plasma Mass Spectrometry. New York: Wiley-VCH. pp. 615–679. ISBN 978-0-471-18620-5.
  5. ↑ "US Patent 7,135,296". Google Patents. 2000-12-28. Retrieved 6 December 2022.
  6. ↑ "Fluidigm Renamed to Stanard BioTools". Globenewswirel. 2022-04-04. Retrieved 9 December 2022.
  7. 1 2 3 4 5 6 "Scott Tanner Biography" (PDF). StemSpecs. Nov 2005. Archived from the original (PDF) on 2009-07-04.
  8. 1 2 3 4 5 Ben Merison (August 6, 2009). "Interview: Raising the Bar". Highlights in Chemical Technology. 2009 (9): T65–T72. Archived from the original on 2012-10-24.
  9. ↑ "Atonic Spectrometry Viewpoint: Scott Tanner". Journal of Analytical Atomic Spectrometry. 10 (1). January 1995.
  10. ↑ "Scott D. Tanner Patents". Google Patents. Retrieved 6 December 2022.
  11. ↑ "President - DVS Sciences". 2009. Archived from the original on 2009-06-19.
  12. ↑ Holland, J. Grenville; Tanner, Scott D., eds. (4 August 2003). Plasma Source Mass Spectrometry: Applications and Emerging Technologies. Royal Society of Chemistry. ISBN 0854046038.
  13. ↑ Holland, J. Grenville; Tanner, Scott D., eds. (2001). Plasma Source Mass Spectrometry : The New Millennium. Cambridge: Royal Society of Chemistry. ISBN 0854048952.
  14. ↑ Holland, Grenville; Tanner, Scott D. Tanner, eds. (23 July 1999). Plasma Source Mass Spectrometry: New Developments and Applications. Cambridge, UK: Royal Society of Chemistry. ISBN 0854047492.
  15. ↑ Holland, Grenville; Tanner, Scott D., eds. (1997). Plasma Source Mass Spectrometry : Developments and Applications. Cambridge: Royal Society of Chemistry. ISBN 0854047271.
  16. ↑ T. Sakuma; N. Gurprasad; S.D. Tanner; A. Ngo; W.R. Davidson; H.A. McLeod; B.P-Y Lau; J.J. Ryan (1985). "The Application of Rapid Gas Chromatographic Tandem Mass Spectrometry in the Analysis of Complex Samples for Chlorinated Dioxins and Furans". In Keith, L.H.; Rappe, C.; Choudhary, G. (eds.). Chlorinated Dioxins and Dibenzofurans in the Total Environment II. p. 139. OL 21212149M.
  17. ↑ The Instantaneous Detection of Explosives by Tandem Mass Spectrometry, S.D. Tanner, W.R. Davidson and J.E. Fulford. Quantico, Virginia: US Dept of Justice. 1983.
  18. ↑ "The Use of a Commercially Available Atmospheric Pressure Chemical Ionization Tandem Quadrupole Mass Spectrometer for the Direct Detection of Chemical Agents and Simulants, B.A. Petersen, S.D. Tanner, J.E. Fulford, B.I. Shushan and W.R. Davidson". Proc.of the 1985 Sci. Conf. On Chem. Defence Research, CRDC-SP-86007. Aberdeen Proving Ground,Maryland: USAAMCC: 15. 1986.
  19. ↑ E.R. Denoyer; D. Jacques; E. Debrah; S.D. Tanner (1995). "Determination of Trace Elements in Uranium: Practical Benefits of a New ICP-MS Lens System". Atomic Spectroscopy. 16 (1).
  20. ↑ Vladimir I. Baranov; Scott D. Tanner (1999). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). I. The RF-Field Energy Contribution in Thermodynamics of Ion-Molecule Reactions". Journal of Analytical Atomic Spectrometry. 14 (8): 1133–1142. doi:10.1039/a809889a.
  21. ↑ S.D. Tanner; V.I. Baranov (November 1999). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). II. Reduction of Interferences Produced Within the Cell". Journal of the American Society for Mass Spectrometry. 10 (11): 1083–1094. doi:10.1016/S1044-0305(99)00081-1. S2CID 93608392.
  22. ↑ Scott D. Tanner; Vladimir I. Baranov; Uwe Vollkopf (2000). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). III. Analytical Performance". Journal of Analytical Atomic Spectrometry. 9 (15): 1261–1269.
  23. ↑ Marcia Kaye (September 13, 2011). "Seeing Into The Soul of Cells". University of Toronto.
  24. ↑ "Lifetime Achievement Award in Plasma Spectrochemistry". Spectroscopyonline. 2020-01-13.
  25. ↑ "HUPO Awards - 2019 RECIPIENTS". HUPO. 2019.
  26. ↑ "CyTOF Inventors Receive Prestigious Science and Technology Award from the Human Proteome Organization (HUPO)". Bloomberg. Bloomberg.com. September 18, 2019.
  27. ↑ "AIMBE College of Fellows Class of 2014". AIMBE. 2014.
  28. ↑ "U of T's 2011 Inventor of the Year". UToronto. 2011.
  29. ↑ Nicolò Omenetto; Greet de Loos (20 September 2004). "Elsevier/Spectrochimica Acta Atomic Spectroscopy Award 2002". Spectrochimica Acta Part B: Atomic Spectroscopy. 59 (9): 1335. Bibcode:2004AcSpe..59.1335O. doi:10.1016/j.sab.2004.08.002. ISSN 0584-8547.
  30. ↑ "Manning Awards - Award of Distinction". Manningawards. 2001. Archived from the original on 2016-08-17.
  31. ↑ Gwyn Morgan (Feb 8, 2010). "Manning Award laureates on the cutting edge". TheGlobeAndMail.com. The Globe and Mail. Archived from the original on 2014-02-14.
  32. ↑ "1999 Pittcon Editors' Awards". OOcities.org. May 1999.
  33. ↑ "Fellow of the Royal Society of Chemistry". RSC.org.
  34. ↑ "Fellow of the American Institute for Medical and Biological Engineering". AIMBE.org. 2014.
  35. ↑ Sean C. Bendall; Erin F. Simonds; Peng Qiu; El-ad D. Amir; Peter O. Krutzik; Rachel Finck; Robert V. Bruggner; Rachel Melamed; Angelica Trejo; Olga I. Ornatsky; Robert S. Balderas; Sylvia K. Plevritis; Karen Sachs; Dana Pe’er; Scott D. Tanner; Garry P. Nolan (May 2011). "Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum". Science. American Association for the Advancement of Science. 332 (6030): 6813–6822. Bibcode:2011Sci...332..687B. doi:10.1126/science.1198704. PMC 3273988. PMID 21551058.
  36. ↑ Olga Ornatsky; Dmitry Bandura; Vladimir Baranov; Mark Nitz; Mitchell A Winnik; Scott Tanner (September 2010). "Highly Multiparametric Analysis by Mass Cytometry". Journal of Immunological Methods. Elsevier. 361 (1–2): 1–20. doi:10.1016/j.jim.2010.07.002. PMID 20655312.
  37. ↑ Dmitry R Bandura; Vladimir I Baranov; Olga I Ornatsky; Alexei Antonov; Robert Kinach; Xudong Lou; Serguei Pavlov; Sergey Vorobiev; John E Dick; Scott D Tanner (Aug 2009). "Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-Of-Flight Mass Spectrometry". Analytical Chemistry. American Chemical Society. 81 (16): 6813–6822. doi:10.1021/ac901049w. PMID 19601617.
  38. ↑ Scott D. Tanner; Vladimir I. Baranov; Dmitry R. Bandura (September 2002). "Reaction Cells and Collision Cells for ICP-MS: A Tutorial Review". Spectrochimica Acta Part B: Atomic Spectroscopy. Elsevier. 57 (9): 1361–1452. Bibcode:2002AcSpe..57.1361T. doi:10.1016/S0584-8547(02)00069-1.
  39. ↑ Vladimir I. Baranov; Zoë Quinn; Dmitry R. Bandura; Scott D. Tanner (April 2002). "A Sensitive and Quantitative Element-Tagged Immunoassay with ICPMS Detection". Analytical Chemistry. American Chemical Society. 74 (7): 1629–1636. doi:10.1021/ac0110350. PMID 12033255.
  40. ↑ Dmitry R. Bandura; Vladimir I. Baranov; Scott D. Tanner (April 2002). "Detection of Ultratrace Phosphorus and Sulfur by Quadrupole ICPMS with Dynamic Reaction Cell". Analytical Chemistry. American Chemical Society. 74 (7): 1497–1502. doi:10.1021/ac011031v. PMID 12033236.
  41. ↑ Dmitry R. Bandura; Vladimir I. Baranov; Scott D. Tanner (July 2001). "Reaction Chemistry and Collisional Processes in Multipole Devices for Resolving Isobaric Interferences in ICP–MS". Fresenius' Journal of Analytical Chemistry. Springer-Verlag. 370 (5): 454–470. doi:10.1007/s002160100869. PMID 11496972. S2CID 20007527.
  42. ↑ Scott D. Tanner; Vladimir I. Baranov; Uwe Vollkopf (August 2000). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). Part III". Journal of Analytical Atomic Spectrometry. Royal Society of Chemistry. 15 (9): 1261–1269. doi:10.1039/b002604m.
  43. ↑ Scott D. Tanner; Vladimir I. Baranov (November 1999). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). Part II. Reduction of Interferences Pproduced within the Cell". Journal of the American Society for Mass Spectrometry. Springer-Verlag. 10 (11): 1083–1094. doi:10.1016/S1044-0305(99)00081-1. S2CID 93608392.
  44. ↑ Scott D. Tanner; Vladimir I. Baranov (March 1999). "Theory, Design, and Operation of a Dynamic Reaction Cell for ICP-MS". Atomic Spectroscopy - Norwalk Connecticut. Atomic Spectroscopy. 20: 45–52.
  45. ↑ Scott D. Tanner (January 1995). "Characterization of Ionization and Matrix Suppression in Inductively Coupled 'Cold' Plasma Mass Spectrometry". Journal of Analytical Atomic Spectrometry. The Royal Society of Chemistry. 10 (11): The Royal Society of Chemistry.
  46. ↑ Scott D Tanner (June 1992). "Space Charge in ICP-MS: Calculation and Implications". Spectrochimica Acta Part B: Atomic Spectroscopy. Elsevier. 47 (6): 809–823. Bibcode:1992AcSpe..47..809T. doi:10.1016/0584-8547(92)80076-S.
  47. ↑ George R. Gillson; Donald J. Douglas; John E. Fulford; Kenneth W Halligan; Scott D. Tanner (July 1988). "Nonspectroscopic Interelement Interferences in Inductively Coupled Plasma Mass Spectrometry". Analytical Chemistry. American Chemical Society. 60 (14): 1472–1474. doi:10.1021/ac00165a024.
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