Shelly Peyton
Alma materUniversity of California, Irvine
Northwestern University
Scientific career
InstitutionsUniversity of Massachusetts Amherst
Massachusetts Institute of Technology
ThesisTissue engineering in the cardiovascular system : mechanically tunable biomaterials to direct smooth muscle cell phenotype. (2007)
WebsitePeyton Lab

Shelly R. Peyton is an American chemical engineer who is the Armstrong Professional Development Professor in the Department of CHemical Engineering at the University of Massachusetts Amherst. Her research considers the development of biomaterials to investigate metastatic cancer and potential new therapies.

Early life and education

Peyton was an undergraduate student at Northwestern University, where she majored in chemical engineering.[1] She was a member of the ultimate frisbee team.[2] Peyton moved to the University of California, Irvine, where she worked on tissue engineering for the cardiovascular system in the research group of Andy Putnam.[3][4] Peyton moved to the Massachusetts Institute of Technology where she was appointed a National Institutes of Health Ruth L. Kirschstein Postdoctoral Fellow.[5] At MIT, Peyton was trained in stem cell biology by Linda Griffith.[6][7] Together they investigated mesenchymal stem cell migration.[5][7]

Research and career

In 2011, Peyton joined the University of Massachusetts Amherst,[5] where she established a research program in the design and application of biomaterials. She was made the Barry and Afsaneh Siadat Career Development Fellow in 2012.

Peyton investigated the fundamental mechanisms that underpin metastasis through the engineering of carefully controlled environments. The series of events includes crosstalk between stem cells and tumours, the mobilization of stem cells, the reassembly of pre-metastatic tissue and the movement of circulating stem cells to tissue sites.[8] In particular, Peyton is interested in the role of stem cells in the metastatic spread of breast cancer.[6] She argued that the stem cells remodel the target organ, altering the mechanical properties of the organ before the cancer cells attack.[6] The controlled environments created by Peyton mimic human organs, allowing Peyton to study how cancer cells embedded in these artificial tissues respond to different forms of chemotherapy.[9] Specifically, the three-dimensional tumour spheroids allow Peyton to precisely control and study the response of biological tissue to cancer cells and therapies.[9]

Peyton worked with Sandra Petersen to develop the Postbaccalaureate Research Education Program (PREP), a $1.7 million National Science Foundation program that looks to improve diversity in the biomedical workforce.[10] In particular, PREP provides funding to doctoral students from historically marginalized groups.[10]

Awards and honors

Selected publications

  • Shelly R Peyton; Andrew J. Putnam (1 July 2005). "Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion". Journal of Cellular Physiology. 204 (1): 198–209. doi:10.1002/JCP.20274. ISSN 0021-9541. PMID 15669099. Wikidata Q45255637.
  • Shelly R Peyton; Christopher B Raub; Vic P Keschrumrus; Andrew J. Putnam (9 June 2006). "The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells". Biomaterials. 27 (28): 4881–4893. doi:10.1016/J.BIOMATERIALS.2006.05.012. ISSN 0142-9612. PMID 16762407. Wikidata Q46018293.
  • Chirag B Khatiwala; Shelly R. Peyton; Andrew J. Putnam (11 January 2006). "Intrinsic mechanical properties of the extracellular matrix affect the behavior of pre-osteoblastic MC3T3-E1 cells". American Journal of Physiology - Cell Physiology. 290 (6): C1640-50. doi:10.1152/AJPCELL.00455.2005. ISSN 0363-6143. PMID 16407416. Wikidata Q40330994.

Personal life

Peyton married her wife in 2016.[14] Peyton is involved with various initiatives to support LGBTQIA+ researchers at the University of Massachusetts Amherst and Biomedical Engineering Society, and was encouraged to do so by Naomi Chesler.[14]

References

  1. ↑ "Dr. Shelly Peyton". www.aiche.org. 2020-10-28. Retrieved 2021-03-16.
  2. ↑ "Shelly Peyton". 2012-06-25. Retrieved 2021-03-16.
  3. ↑ Peyton, Shelly Renae (2007). Tissue engineering in the cardiovascular system: mechanically tunable biomaterials to direct smooth muscle cell phenotype (Thesis). OCLC 212928781.
  4. ↑ "ALUMNI". The Putnam Lab. Retrieved 2021-03-16.
  5. 1 2 3 "College Welcomes Shelly Peyton | Chemical Engineering | UMass Amherst". che.umass.edu. Retrieved 2021-03-16.
  6. 1 2 3 4 "Shelly Peyton, UMass Amherst Chemical Engineer, Named 2013 Pew Scholar in Biomedical Science". Office of News & Media Relations | UMass Amherst. Retrieved 2021-03-16.
  7. 1 2 "Special Bioengineering Seminar: Shelly Peyton | Fischell Department of Bioengineering". bioe.umd.edu. Retrieved 2021-03-16.
  8. ↑ "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2021-03-16.
  9. 1 2 3 "UMass Amherst Chemical Engineer Shelly Peyton Gets NSF CAREER Grant to Study Cancer and Development of Chemotherapy Drugs". Office of News & Media Relations | UMass Amherst. Retrieved 2021-03-16.
  10. 1 2 "PREP Program for Diversity in STEM Graduate Programs Awarded $1.7 Million Grant". Office of News & Media Relations | UMass Amherst. Retrieved 2021-03-16.
  11. ↑ "NIH Director's New Innovator Award - Funded Research". commonfund.nih.gov. 2013-06-26. Retrieved 2021-03-16.
  12. ↑ "College of Engineering Annual Report 2016". Issuu. Retrieved 2021-03-16.
  13. ↑ "Dr. Shelly Peyton to present 2018 Mellichamp Lecture". Davidson School of Chemical Engineering - Purdue University. Retrieved 2021-03-16.
  14. 1 2 "Shelly Peyton: Featured LGBTQ+ ChemE Professional". www.aiche.org. 2020-06-16. Retrieved 2021-03-16.
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