The SraL RNA ('sra' for small RNA), also known as RyjA, is a small non-coding RNA discovered in E. coli,[1][2] and later in Salmonella Tiphimurium.[3][4] This ncRNA was found to be expressed only in stationary phase.[1] It may possibly play a role in Salmonella virulence.[3] The major stationary phase regulator RpoS is transcriptionally regulating SraL and directly binds to the sraL gene promoter. SraL down-regulates the expression of the ribosome-associated chaperone Trigger Factor (TF), which is involved in the folding of the newly synthesised cystolic proteins.[5]

References

  1. 1 2 Argaman, L.; Hershberg, R.; Vogel, J.; Bejerano, G.; Wagner, E. G.; Margalit, H.; Altuvia, S. (2001-06-26). "Novel small RNA-encoding genes in the intergenic regions of Escherichia coli". Current Biology. 11 (12): 941–950. doi:10.1016/s0960-9822(01)00270-6. ISSN 0960-9822. PMID 11448770.
  2. ↑ Wassarman, K. M.; Repoila, F.; Rosenow, C.; Storz, G.; Gottesman, S. (2001-07-01). "Identification of novel small RNAs using comparative genomics and microarrays". Genes & Development. 15 (13): 1637–1651. doi:10.1101/gad.901001. ISSN 0890-9369. PMC 312727. PMID 11445539.
  3. 1 2 Viegas, Sandra C.; Pfeiffer, Verena; Sittka, Alexandra; Silva, Inês J.; Vogel, Jörg; Arraiano, Cecília M. (2007). "Characterization of the role of ribonucleases in Salmonella small RNA decay". Nucleic Acids Research. 35 (22): 7651–7664. doi:10.1093/nar/gkm916. ISSN 1362-4962. PMC 2190706. PMID 17982174.
  4. ↑ Ortega, Alvaro D.; Gonzalo-Asensio, Jesús; García-del Portillo, Francisco (April 2012). "Dynamics of Salmonella small RNA expression in non-growing bacteria located inside eukaryotic cells". RNA Biology. 9 (4): 469–488. doi:10.4161/rna.19317. ISSN 1555-8584. PMID 22336761.
  5. ↑ Silva, Inês Jesus; Ortega, Alvaro Darío; Viegas, Sandra Cristina; García-Del Portillo, Francisco; Arraiano, Cecília Maria (September 2013). "An RpoS-dependent sRNA regulates the expression of a chaperone involved in protein folding". RNA. 19 (9): 1253–1265. doi:10.1261/rna.039537.113. ISSN 1469-9001. PMC 3753932. PMID 23893734.


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