Stimulator of chondrogenesis 1

SCRG1
Identifiers
Aliases	SCRG1, SCRG-1, stimulator of chondrogenesis 1
External IDs	OMIM: 603163 MGI: 1328308 HomoloGene: 5269 GeneCards: SCRG1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	173,406,380 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	57,930,619 bp
RNA expression pattern
	Top expressed in
	tibia; ; external globus pallidus; ; subthalamic nucleus; ; saphenous vein; ; inferior ganglion of vagus nerve; ; optic nerve; ; superior vestibular nucleus; ; pons; ; ventral tegmental area; ; internal globus pallidus;
	Top expressed in
	optic nerve; ; globus pallidus; ; superior frontal gyrus; ; cerebellar cortex; ; entorhinal cortex; ; cerebellar vermis; ; lateral hypothalamus; ; subiculum; ; dorsal tegmental nucleus; ; lesser wing of sphenoid bone;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi apparatus; neuron projection terminus; extracellular region; cytoplasm; extracellular space;
Biological process	nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	11341
	20284
	ENSG00000164106
	ENSMUSG00000031610
	O75711
	O88745
	NM_007281; NM_001329597
	NM_009136
	NP_001316526; NP_009212
	NP_033162
	Wikidata
View/Edit Human	View/Edit Mouse

Stimulator of chondrogenesis 1 is a protein that in humans is encoded by the SCRG1 gene. ^[5]

Function

Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164106 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031610 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Stimulator of chondrogenesis 1". Retrieved 2018-10-01.

Aomatsu E, Takahashi N, Sawada S, Okubo N, Hasegawa T, Taira M, Miura H, Ishisaki A, Chosa N (January 2014). "Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells". Sci Rep. 4: 3652. Bibcode:2014NatSR...4E3652A. doi:10.1038/srep03652. PMC 3888969. PMID 24413464.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164106 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031610 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Stimulator of chondrogenesis 1". Retrieved 2018-10-01.

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Function

References

Further reading