THOC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTHOC1, HPR1, P84, P84N5, THO complex 1
External IDsOMIM: 606930 MGI: 1919668 HomoloGene: 38012 GeneCards: THOC1
Orthologs
SpeciesHumanMouse
Entrez

9984

225160

Ensembl

ENSG00000079134

ENSMUSG00000024287

UniProt

Q96FV9

Q8R3N6

RefSeq (mRNA)

NM_005131

NM_153552

RefSeq (protein)

NP_005122

NP_705780

Location (UCSC)Chr 18: 0.21 – 0.27 MbChr 18: 9.96 – 10 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

THO complex subunit 1 is a protein that in humans is encoded by the THOC1 gene.[5][6]

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM][6]

Interactions

THOC1 has been shown to interact with Retinoblastoma protein.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000079134 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024287 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.
  6. 1 2 "Entrez Gene: THOC1 THO complex 1".
  7. Durfee, T; Mancini M A; Jones D; Elledge S J; Lee W H (November 1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing". J. Cell Biol. 127 (3): 609–22. doi:10.1083/jcb.127.3.609. ISSN 0021-9525. PMC 2120229. PMID 7525595.

Further reading


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