THRSP
Identifiers
AliasesTHRSP, LPGP1, Lpgp, S14, SPOT14, THRP, thyroid hormone responsive
External IDsOMIM: 601926 MGI: 109126 HomoloGene: 2441 GeneCards: THRSP
Orthologs
SpeciesHumanMouse
Entrez

7069

21835

Ensembl

ENSG00000151365

ENSMUSG00000035686

UniProt

Q92748

Q62264

RefSeq (mRNA)

NM_003251

NM_009381

RefSeq (protein)

NP_003242

NP_033407

Location (UCSC)Chr 11: 78.06 – 78.07 MbChr 7: 97.06 – 97.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thyroid hormone-inducible hepatic protein is a protein that in humans is encoded by the THRSP gene.[5][6]

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors.

This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.[6]

Previously, THRSP was among the identified upregulated genes in the prefrontal cortex of spontaneously hypertensive rats (SHR/NCrl) and Wistar-Kyoto (WKY/NCrl) rats which exhibited inattention behavior.[7] Subsequently, overexpression of THRSP induced inattention, but not hyperactive and impulsive behavior in mice, suggesting that this gene plays a role in the inattention phenotype of ADHD.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000151365 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035686 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R (Feb 1997). "Cloning and initial characterization of human and mouse Spot 14 genes". FEBS Lett. 401 (1): 38–42. doi:10.1016/S0014-5793(96)01433-0. PMID 9003802. S2CID 44575293.
  6. 1 2 "Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)".
  7. dela Peña, Ike; Bang, Minji; Lee, Jinhee; de la Peña, June Bryan; Kim, Bung-Nyun; Han, Doug Hyun; Noh, Minsoo; Shin, Chan Young; Cheong, Jae Hoon (September 2015). "Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior". Behavioural Brain Research. 291: 268–276. doi:10.1016/j.bbr.2015.05.012. PMID 26048425. S2CID 9853684.
  8. Custodio, Raly James Perez; Botanas, Chrislean Jun; de la Peña, June Bryan; dela Peña, Irene Joy; Kim, Mikyung; Sayson, Leandro Val; Abiero, Arvie; Ryoo, Zae Young; Kim, Bung-Nyun; Kim, Hee Jin; Cheong, Jae Hoon (October 2018). "Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice". Neuroscience. 390: 141–150. doi:10.1016/j.neuroscience.2018.08.008. PMID 30138648. S2CID 52075574.

Further reading


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