TPPP

TPPP
Identifiers
Aliases	TPPP, TPPP/p25, TPPP1, p24, p25, p25alpha, tubulin polymerization promoting protein
External IDs	OMIM: 608773 MGI: 1920198 HomoloGene: 21389 GeneCards: TPPP
Gene location (Human)
Chr.	Chromosome 5 (human)
End	693,352 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	74,183,872 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; postcentral gyrus; ; internal globus pallidus; ; entorhinal cortex; ; inferior ganglion of vagus nerve; ; superior frontal gyrus; ; ventral tegmental area; ; superior vestibular nucleus; ; subthalamic nucleus;
	Top expressed in
	primary motor cortex; ; ventral tegmental area; ; cingulate gyrus; ; piriform cortex; ; dentate gyrus; ; superior colliculus; ; lateral hypothalamus; ; subiculum; ; suprachiasmatic nucleus; ; globus pallidus;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; protein binding; tubulin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; myelin sheath; microtubule; cytoskeleton; nucleus; mitochondrion; cytosol; microtubule bundle;
Biological process	microtubule polymerization; positive regulation of protein-containing complex assembly; positive regulation of protein polymerization; microtubule bundle formation;
	Sources:Amigo / QuickGO
Orthologs
	11076
	72948
	ENSG00000171368
	ENSMUSG00000021573
	O94811
	Q7TQD2
	NM_007030
	NM_182839
	NP_008961
	NP_878259
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.^[5]^[6]^[7]^[8]^[9]

This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.^[10]

This has also been linked to Parkinson's and Alzheimer's Disease^[11]^[12]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171368 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021573 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T (Apr 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet. 44 (2): 121–2. doi:10.1007/s100380050122. PMID 10083737.
↑ Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (Jul 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–64. doi:10.1021/bi020140g. PMID 12093283.
↑ Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem. 280 (7): 5703–15. doi:10.1074/jbc.M410409200. PMID 15590652.
↑ Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J (Nov 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–26. doi:10.1021/bi061305e. PMID 17105200.
↑ "Entrez Gene: TPPP brain-specific protein p25 alpha".
↑ Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. 409 (1): 137–41. doi:10.1016/j.bbrc.2011.04.130. PMID 21565174.
↑ Kovács, Gábor G.; László, Lajos; Kovács, János; Jensen, Poul Henning; Lindersson, Evo; Botond, Gergő; Molnár, Tamás; Perczel, András; Hudecz, Ferenc (2004-11-01). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006. PMID 15474353. S2CID 42518910.
↑ Kovács, Gábor G.; Gelpi, Ellen; Lehotzky, Attila; Höftberger, Romana; Erdei, Anna; Budka, Herbert; Ovádi, Judit (2006-11-23). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica. 113 (2): 153–161. doi:10.1007/s00401-006-0167-4. ISSN 0001-6322. PMID 17123092. S2CID 28792202.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Martín CP, Vázquez J, Avila J, Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor". Biochim. Biophys. Acta. 1586 (1): 113–22. doi:10.1016/s0925-4439(01)00092-8. hdl:10261/252211. PMID 11781156.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tirián L, Hlavanda E, Oláh J, et al. (2004). "TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 13976–81. doi:10.1073/pnas.2436331100. PMC 283531. PMID 14623963.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lehotzky A, Tirián L, Tökési N, et al. (2005). "Dynamic targeting of microtubules by TPPP/p25 affects cell survival". J. Cell Sci. 117 (Pt 25): 6249–59. doi:10.1242/jcs.01550. hdl:21.11116/0000-0002-1119-F. PMID 15564385.
DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
Jämsä A, Bäckström A, Gustafsson E, et al. (2006). "Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells". Biochem. Biophys. Res. Commun. 345 (1): 324–31. doi:10.1016/j.bbrc.2006.04.032. PMID 16678793.
Skjoerringe T, Lundvig DM, Jensen PH, Moos T (2006). "P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain". J. Neurochem. 99 (1): 333–42. doi:10.1111/j.1471-4159.2006.04073.x. PMID 16879710. S2CID 86488870.
Oláh J, Tokési N, Vincze O, et al. (2006). "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies". FEBS Lett. 580 (25): 5807–14. doi:10.1016/j.febslet.2006.09.037. PMID 17027006. S2CID 1513728.
Hlavanda E, Klement E, Kókai E, et al. (2007). "Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases". J. Biol. Chem. 282 (40): 29531–9. doi:10.1074/jbc.M703466200. hdl:2437/3435. PMID 17693641.
Song YJ, Lundvig DM, Huang Y, et al. (2007). "p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy". Am. J. Pathol. 171 (4): 1291–303. doi:10.2353/ajpath.2007.070201. PMC 1988878. PMID 17823288.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171368 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021573 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10083737-5] Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T (Apr 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet. 44 (2): 121–2. doi:10.1007/s100380050122. PMID 10083737.

[pmid12093283-6] Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (Jul 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–64. doi:10.1021/bi020140g. PMID 12093283.

[pmid15590652-7] Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem. 280 (7): 5703–15. doi:10.1074/jbc.M410409200. PMID 15590652.

[pmid17105200-8] Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J (Nov 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–26. doi:10.1021/bi061305e. PMID 17105200.

[entrez-9] "Entrez Gene: TPPP brain-specific protein p25 alpha".

[pmid21565174-10] Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. 409 (1): 137–41. doi:10.1016/j.bbrc.2011.04.130. PMID 21565174.

[11] Kovács, Gábor G.; László, Lajos; Kovács, János; Jensen, Poul Henning; Lindersson, Evo; Botond, Gergő; Molnár, Tamás; Perczel, András; Hudecz, Ferenc (2004-11-01). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006. PMID 15474353. S2CID 42518910.

[12] Kovács, Gábor G.; Gelpi, Ellen; Lehotzky, Attila; Höftberger, Romana; Erdei, Anna; Budka, Herbert; Ovádi, Judit (2006-11-23). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica. 113 (2): 153–161. doi:10.1007/s00401-006-0167-4. ISSN 0001-6322. PMID 17123092. S2CID 28792202.

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Further reading