TRAK1

TRAK1
Identifiers
Aliases	TRAK1, MILT1, OIP106, trafficking kinesin protein 1, EIEE68, DEE68
External IDs	OMIM: 608112 MGI: 1914345 HomoloGene: 25103 GeneCards: TRAK1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	42,225,890 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	121,303,984 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pylorus; ; bronchial epithelial cell; ; nipple; ; frontal pole; ; gastrocnemius muscle; ; left ventricle; ; trachea; ; Brodmann area 10; ; thoracic diaphragm;
	Top expressed in
	aortic valve; ; ascending aorta; ; myocardium of ventricle; ; superior frontal gyrus; ; ankle joint; ; stria vascularis; ; lip; ; Region I of hippocampus proper; ; supraoptic nucleus; ; soleus muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; GABA receptor binding; TPR domain binding; signaling receptor binding; myosin binding;
Cellular component	cytoplasm; endosome; early endosome; mitochondrion; nucleus; axon cytoplasm; dendrite; axonal growth cone; perinuclear region of cytoplasm; cytoplasmic vesicle; dendrite cytoplasm; cell cortex; membrane; mitochondrial membrane;
Biological process	regulation of transcription by RNA polymerase II; protein targeting; protein O-linked glycosylation; endosome to lysosome transport; anterograde axonal transport of mitochondrion; axonal transport of mitochondrion; dendrite morphogenesis; positive regulation of axonogenesis; anterograde axonal transport; protein localization; neurogenesis; vesicle transport along microtubule; mitochondrion distribution;
	Sources:Amigo / QuickGO
Orthologs
	22906
	67095
	ENSG00000182606
	ENSMUSG00000032536
	Q9UPV9
	Q6PD31
NM_001042646; NM_001265608; NM_001265609; NM_001265610; NM_014965;
	NM_001349245; NM_001349246; NM_001349247; NM_001349248; NM_001349249
NM_175114; NM_001357968; NM_001357969; NM_001357970; NM_001357972;
	NM_001357973
NP_001036111; NP_001252537; NP_001252538; NP_001252539; NP_055780;
	NP_001336174; NP_001336175; NP_001336176; NP_001336177; NP_001336178
NP_780323; NP_001344897; NP_001344898; NP_001344899; NP_001344901;
	NP_001344902
	Wikidata
View/Edit Human	View/Edit Mouse

Trafficking kinesin-binding protein 1 is a protein that in humans is encoded by the TRAK1 gene.^[5]^[6]^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182606 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032536 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
↑ Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J Biol Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
↑ Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Jan 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nat Genet. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713. S2CID 20231963.
↑ "Entrez Gene: TRAK1 trafficking protein, kinesin binding 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Iyer SP, Hart GW (2003). "Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity". J. Biol. Chem. 278 (27): 24608–16. doi:10.1074/jbc.M300036200. PMID 12724313.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. CiteSeerX 10.1.1.123.3574. doi:10.1167/iovs.04-1380. PMID 15851553.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182606 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032536 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10470851-5] Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.

[pmid12435728-6] Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J Biol Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.

[pmid16380713-7] Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Jan 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nat Genet. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713. S2CID 20231963.

[entrez-8] "Entrez Gene: TRAK1 trafficking protein, kinesin binding 1".

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References

Further reading