TRIM69
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NQJ
Identifiers
Aliases	TRIM69, HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69
External IDs	OMIM: 616017 MGI: 1918178 HomoloGene: 18827 GeneCards: TRIM69
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.1 Start 44,728,988 bp[1] End 44,767,829 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 121,991,181 bp[2] End 122,009,508 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus prefrontal cortex skeletal muscle tissue putamen left ventricle caudate nucleus dorsolateral prefrontal cortex nucleus accumbens substantia nigra superior frontal gyrus Top expressed in spermatid spermatocyte seminiferous tubule morula jejunum endocrine system pancreas islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component cytoplasm nuclear speck nucleus cytosol Biological process protein ubiquitination apoptotic process protein polyubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140691 70928 Ensembl ENSG00000278211 ENSG00000185880 ENSMUSG00000033368 UniProt Q86WT6 Q80X56 RefSeq (mRNA) NM_182985 NM_001301144 NM_001301145 NM_001301146 NM_080745 NM_080510 NM_001379369 RefSeq (protein) NP_001288073 NP_001288074 NP_001288075 NP_542783 NP_892030 NP_536771 NP_001366298 Location (UCSC) Chr 15: 44.73 – 44.77 Mb Chr 2: 121.99 – 122.01 Mb PubMed search [3] [4]
Wikidata
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Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. ^[5]

Function

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

References

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human E3 ubiquitin-protein ligase TRIM69

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.