Tanmay A. M. Bharat is a programme leader in the Structural Studies Division of the MRC Laboratory of Molecular Biology.[1] He and his group use electron tomography, together with several structural and cell biology methods to study the cell surfaces of bacteria and archaea. His work has increased the understanding of how surface molecules help in the formation of multicellular communities of prokaryotes, examples of which include biofilms and microbiomes.[2] He has been awarded several prizes and fellowships for his work.[3][4]

Education

Bharat graduated with a BA in Biological Sciences from the University of Oxford, UK. His studies were supported by a Rhodes Scholarship. He then undertook research at the European Molecular Biology Laboratory in Heidelberg, Germany for his PhD working with John A. G. Briggs.[5] He studied the structure and assembly of pathogenic viruses using cryogenic electron microscopy and tomography. His work on several viral capsid proteins improved understanding of how viruses are assembled within infected cells.[6][7][8][9]

Research

He subsequently joined the MRC Laboratory of Molecular Biology (LMB) in Cambridge to pursue post-doctoral research with Jan Löwe using cryo-EM to study proteins within bacterial cells.[5][10][11][12] After his post-doctoral appointment concluded, he was recruited to the Sir William Dunn School of Pathology, University of Oxford as a Wellcome Trust and Royal Society Sir Henry Dale Fellow.[13] After obtaining tenure at Oxford, he moved back to the LMB as a programme leader in 2022.[14] His research investigates how bacteria and archaea use their surface molecules to form multicellular communities. For instance, during human infections bacteria form biofilms that help them evade antibiotics. The group also use electron tomography.[6]

Scientific publications

Bharat is the author or co-author of over 46 scientific publications. These include:

Awards

Bharat has been awarded many prizes and fellowships.[5] These include a 2018 Vallee Research Scholarship,[5] the 2019 EMBL John Kendrew Award[15] the 2020 Philip Leverhulme Prize for Biological Sciences,[16] the 2021 Eppendorf Award for Young European Investigators,[17] and the 2021 Lister Prize,[18] the 2022 Colworth Medal from the Biochemical Society[6] and the 2023 Fleming Prize from the Microbiology Society.[4]

References

  1. ↑ Biology, ©2023 MRC Laboratory of Molecular; Avenue, Francis Crick; Campus, Cambridge Biomedical; CB2 0QH, Cambridge; Uk. 01223 267000. "Tanmay Bharat". MRC Laboratory of Molecular Biology. Retrieved 2023-12-12.{{cite web}}: CS1 maint: numeric names: authors list (link)
  2. ↑ "Tanmay Bharat, PhD | The Vallee Foundation". thevalleefoundation.org. Retrieved 2023-12-12.
  3. ↑ "Tanmay Bharat Prokaryotic cell surfaces". MRC Laboratory of Molecular Biology. UKRI. Retrieved 26 October 2023.
  4. 1 2 "FLEMING PRIZE WINNERS". Microbiology Society. Retrieved 28 April 2020.
  5. 1 2 3 4 "Vallee Scholar Awards: Tanmay Bharat, PhD". The Vallee Foundation. Retrieved 26 October 2023.
  6. 1 2 3 "The Colworth Medal". Biochemical Society. Retrieved 8 September 2022.
  7. ↑ Bharat, Tanmay A. M.; Riches, James D.; Kolesnikova, Larissa; Welsch, Sonja; Krähling, Verena; Davey, Norman; Parsy, Marie-Laure; Becker, Stephan; Briggs, John A. G. (2011-11-15). "Cryo-electron tomography of Marburg virus particles and their morphogenesis within infected cells". PLOS Biology. 9 (11): e1001196. doi:10.1371/journal.pbio.1001196. ISSN 1545-7885. PMC 3217011. PMID 22110401.
  8. ↑ Bharat, Tanmay A. M.; Noda, Takeshi; Riches, James D.; Kraehling, Verena; Kolesnikova, Larissa; Becker, Stephan; Kawaoka, Yoshihiro; Briggs, John A. G. (2012-03-13). "Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography". Proceedings of the National Academy of Sciences of the United States of America. 109 (11): 4275–4280. Bibcode:2012PNAS..109.4275B. doi:10.1073/pnas.1120453109. ISSN 1091-6490. PMC 3306676. PMID 22371572.
  9. ↑ Bharat, Tanmay A. M.; Davey, Norman E.; Ulbrich, Pavel; Riches, James D.; de Marco, Alex; Rumlova, Michaela; Sachse, Carsten; Ruml, Tomas; Briggs, John A. G. (2012-07-19). "Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy". Nature. 487 (7407): 385–389. Bibcode:2012Natur.487..385B. doi:10.1038/nature11169. ISSN 1476-4687. PMID 22722831. S2CID 4423300.
  10. ↑ Kostic, Milka. "MasterClass—Optimizing RELION for cryo-ET by Tanmay Bharat and Sjors Scheres". crosstalk.cell.com. Retrieved 2023-12-07.
  11. ↑ Bharat, Tanmay A. M.; Murshudov, Garib N.; Sachse, Carsten; Löwe, Jan (2015-07-02). "Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles". Nature. 523 (7558): 106–110. Bibcode:2015Natur.523..106B. doi:10.1038/nature14356. ISSN 1476-4687. PMC 4493928. PMID 25915019.
  12. ↑ van den Ent, Fusinita; Izoré, Thierry; Bharat, Tanmay Am; Johnson, Christopher M.; Löwe, Jan (2014-05-02). "Bacterial actin MreB forms antiparallel double filaments". eLife. 3: e02634. doi:10.7554/eLife.02634. ISSN 2050-084X. PMC 4051119. PMID 24843005.
  13. ↑ "Structural cell biology of bacterial biofilm formation". Wellcome. Retrieved 2023-12-07.
  14. ↑ "Tanmay Bharat CV". www2.mrc-lmb.cam.ac.uk. Retrieved 2023-12-07.
  15. ↑ "The John Kendrew Award – Alumni relations". Retrieved 2023-12-21.
  16. ↑ "Philip Leverhulme Prizes 2020 | The Leverhulme Trust". www.leverhulme.ac.uk. Retrieved 2023-12-21.
  17. ↑ "2021 Award Winner - Eppendorf Corporate". corporate.eppendorf.com. Retrieved 2023-12-21.
  18. ↑ "Tanmay Bharat Awarded Lister Institute Research Prize". Sir William Dunn School of Pathology. Retrieved 26 October 2023.
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