TNR
Identifiers
AliasesTNR, TN-R, tenascin R, NEDSTO
External IDsOMIM: 601995 MGI: 99516 HomoloGene: 124416 GeneCards: TNR
Orthologs
SpeciesHumanMouse
Entrez

7143

21960

Ensembl

ENSG00000116147

ENSMUSG00000015829

UniProt

Q92752

Q8BYI9

RefSeq (mRNA)

NM_003285
NM_001328635

NM_022312

RefSeq (protein)

NP_001315564
NP_003276
NP_003276.3

NP_071707

Location (UCSC)Chr 1: 175.32 – 175.74 MbChr 1: 159.35 – 159.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tenascin-R is a protein that in humans is encoded by the TNR gene.[5][6][7]

Function

Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes 4 genes in mammals: TNC (or hexabrachion), TNX (TNXB), TNW (also known as TNN) and TNR.[8][9] The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000116147 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015829 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Carnemolla B, Leprini A, Borsi L, Querzé G, Urbini S, Zardi L (April 1996). "Human tenascin-R. Complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24". The Journal of Biological Chemistry. 271 (14): 8157–60. doi:10.1074/jbc.271.14.8157. PMID 8626505.
  6. Leprini A, Gherzi R, Siri A, Querzé G, Viti F, Zardi L (December 1996). "The human tenascin-R gene". The Journal of Biological Chemistry. 271 (49): 31251–4. doi:10.1074/jbc.271.49.31251. PMID 8940128.
  7. 1 2 "Entrez Gene: TNR tenascin R (restrictin, janusin)".
  8. Erickson HP (October 1993). "Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions". Current Opinion in Cell Biology. 5 (5): 869–76. doi:10.1016/0955-0674(93)90037-Q. PMID 7694605.
  9. Hsia, Henry C.; Schwarzbauer, Jean E. (July 2005). "Meet the Tenascins: Multifunctional and Mysterious". Journal of Biological Chemistry. 280 (29): 26641–26644. doi:10.1074/jbc.R500005200. PMID 15932878.

Further reading


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