Shot during a police chase, Kimble seeks refuge at an orphanage near a Navajo Indian reservation in Puma County, Arizona. Annie Johnson removes the bullet and offers Kimble work as a teacher. The local sheriff, Prycer, believes that Kimble has escaped, but his deputy, Steel, believes him to still be in the area and suspects Annie of sheltering the fugitive.

Kimble believes he sees the one-armed man entering an audiovisual trade show at a courtyard-style hotel (filmed on Wilshire Boulevard in Los Angeles, with many, many landmarks making the location obvious). After Kimble runs into a guest and accidentally takes her wallet, on-site security mistakes him for a pickpocket and gives chase. To complicate things, Kimble's visit was caught, for an instant, on videotape, by a saleswoman demonstrating new home-recording technology. Even worse, Kimble was a witness to a burglary that ended in a fatal shooting. An ex-cop now desperately needs Kimble to testify at the inquest to prove that he fired in self-defence -- and he will stop at nothing to bring Kimble in.

Kimble believes he spotted the one-armed man while in Clark City, a corrupt gambling town. In fact he did: the one-armed man works there as a numbers runner under the alias Steve Cramer, and hires two cops to attack Kimble. Kimble survives but "Cramer" puts out a contract on him. Kimble is nursed back to health by Cora, a prostitute (after she first tries stealing his wallet). She tells Kimble that the entire town is under the control of mob underboss Oliver Enright, to whom Kimble goes to ask for protection. Eventually, Kimble and the one-armed man are both brought to the elderly and invalid Mafia boss Victor Luchek, who must decide what to do with the two fugitives in his town.

Kimble is working as an apartment janitor in a down metropolitan city. Roger Roland, a neighbor, murders a woman in the building where Kimble lives by bludgeoning her to death with a marble statue after she refuses his advances. After a tenant reports seeing a figure run from the murder victim's apartment, the police arrive and suspect Kimble despite his alibi. Meanwhile, Gerard arrives to resume his personal search for Kimble. The city in which the story takes place is never identified (aside from not being in Ohio), but it must be close enough to Stafford that Gerard can get there in only a few hours.
Guest Stars: Robert Drivas as Roger, Eduard Franz as Edward Roland, Madlyn Rhue as Liz Roland, Ellen Corby as Mrs. Murdock.

Kimble finds work on Jake Lawrence's farm where he develops a special friendship with Jake's autistic daughter, Cathy. Kimble becomes nervous when a sheriff, Mel Bailey, begins searching for Joe Burmas, a convicted murderer who escaped from prison a few weeks before. Meanwhile, back in Stafford, Gerard is confronting the editor of the local newspaper who self-servingly has established a $10,000 reward for Kimble's capture—and Gerard later learns that someone has responded. Gerard arrives at Jake's farm, where Burmas shows up and takes Cathy hostage, leaving Kimble having to rescue Cathy and escape from Gerard at the same time.
Guest Stars: June Harding as Cathy, Lin McCarthy as Jake, Joe Maross as Bailey, Paul Mantee as Burmas, Simon Scott as Martin Pierce

While working as a veterinarian assistant in rural Utah, Kimble becomes acquainted with Ruth Simmons, an unwed teenage mother with a sickly infant. She is being harassed by a would-be deputy, Pete Edwards. Her father, Joshua, has his own interpretation of religion which prohibits the use of medicine for any human ailment, but he is also driven by bitterness that his daughter's out-of-wedlock birth has shamed him. Kimble brings antibiotics, but Joshua destroys the drugs. After determining that the baby is anemic, Kimble secretly arranges for a blood transfusion. He learns Ruth was to marry a soldier who died in a bus accident. Joshua holds Kimble at gunpoint, but when the baby loses consciousness, Kimble revives him. Joshua, shamed by his attitude, must act when Edwards arrives to arrest Kimble with the aid of two bloodhound dogs.

Now employed by a film supply store as a photo developer, Kimble spots the one-armed man in a photo. After tracking down Howie Keever, a freelance photographer who took the picture, Kimble learns that the one-armed man (now going by the name "Joe Walters") works at a nearby chemical warehouse. Kimble goes there and surprises "Walters". During a scuffle, the one-armed man accidentally ignites some chemicals, creating an explosion which leaves him injured and Kimble blinded by the flash. The one-armed man manages to escape and once again reports Kimble to the police. Kimble must find a way back to Howie's apartment for safety, but Howie and his uncle learn about the $10,000 reward on Kimble and call the police.

Carl Crandall is the wealthy and spoiled son of California winery owner Pete Crandall. Carl stops a labor strike by killing the union leader and framing Morales, another worker. Kimble happens by and witnesses Carl run from the scene of the crime, but he is unable to tell anyone. Kimble tries to write an anonymous letter to the District Attorney, but Carl's goons confiscate the letter. While Kimble tries to persuade Morales' daughter, Elena, to help him report Carl to clear her father, Pete suspects Carl of the murder. He sends his two right-hand men to keep an eye on Carl, but the men side with Carl, who orders them to murder Kimble.

Kimble meets Willie Turner, an intellectually disabled young man who is accused of hurting a child. Kimble reluctantly hides Willie at a carnival where Kimble currently works. Kimble tries to persuade Willie to return to the hospital where his sister had him committed, but when the police discover Kimble, he is forced to run and Willie decides to tag along with him.

After Kimble spots Fred Johnson at the scene of a fire, he gives chase, but stops to help a woman, Maggie Tibbett (guest star Barbara Baxley) who has been hit by a vehicle. After Kimble helps her get to a hospital, he discovers that she is Johnson's girlfriend. Meanwhile, Johnson has contacted her and told her to contact the police.
Guest Stars: Joanna Moore as Ruth Bianchi, Phillip E. Pine as Rowan

While working as a fishing crewman, Kimble becomes embroiled in a union strike organized by Joe Donovan, the son of Kimble's employer, Tony Donovan. During a rally, Kimble, Tony and a few others are arrested. After being released, Kimble tries to leave town before his secret will be revealed. Tony offers to take Kimble to Mexico if the fugitive helps him on his next fishing trip. But Joe sees Tony smuggle Kimble aboard their boat and calls the police.

While fleeing from a sheriff's dragnet, Kimble is rescued by a dangerous motorcycle gang called the Devil's Disciples, led by the brutal Hutch. As payback, Hutch wants Kimble's help in avenging the death of a former gang member who robbed a gas station. His father had turned him in, and as part of his sentence, he was drafted and sent to Vietnam, where he was killed in action. When Kimble notices that the gang is not completely unified, he seeks help from Don, one of the members, and girlfriend Patty to help him escape so he can warn the police to prevent the killing of the deceased gang member's father.

Kimble finds work at an upholstery store, which the police are staking in their search for Bowen, an escaped killer. Kimble becomes acquainted with one worker, a Hungarian immigrant named Josef Karac, who is actually a doctor wanted by the police for an abortion authorities believe he performed years earlier. The police come to Karac's apartment where his wife, daughter, and nephew live, while police officer Jim Macklin goes undercover as a worker at the shop where Bowen was last seen. But Bowen soon returns and takes the Karac family hostage and vows to do anything to escape from the police even if it means killing again.

Kimble works on the ranch of Arthur Brame, unaware that he is a retired Mob hitman. When a horse breaks loose and nearly tramples Brame, Kimble saves his boss' life, and the ranch owner is determined to repay the debt to Kimble. When Brame learns that Lt. Gerard is looking for Kimble, he arranges to steer Gerard into a trap at a warehouse he owns, but Kimble and Brame's wife Sharon race to stop him.
Guest Stars: James Daly as Brame, Elizabeth Allen as Sharon.

While escaping from the police hunting him in the wilderness of Oregon, Kimble meets a wounded criminal who demands that he take him to a rendezvous point in an isolated cabin a few miles away. They reach it only to find it occupied by a woman called Laura Craig. They are joined by the criminal's three accomplices the next day. A tense hostage situation develops when the local sheriff also arrives to look for Kimble.

Now a clerk in a small grocery in Ocean Grove, California, Kimble witnesses the conflict between a co-worker, Larry Corby, and his father, Ben, who's the town's sheriff. Larry has plans he has not told his father, and their relationship is about to change dramatically. Ben refuses to support Larry and his pregnant girlfriend, so the teenager robs the store where Kimble works, but gets shot by Ben during the getaway. After seeing that he shot his own son, Ben captures Kimble and offers to set him free if Kimble gives the boy medical attention.

Ralph Schuyler is a government agent who goes undercover as a boat captain to spy on Felice Greer, the wife of an international embezzler hiding out in Mexico. Kimble is on that boat as a hired deck hand. Ralph learns that Kimble's identity is false, then takes Kimble's fingerprints. After an emergency landing, the agent leaves the fingerprints with a local Mexican shopkeeper and notifies the authorities of Felice's whereabouts.

Kimble, a construction worker in Nebraska, is recognized by the building contractor, Alex "Pat" Patton, who once built a theater in his hometown, only to have a wall collapse due to faulty construction and killed three children. Although exonerated of manslaughter charges, the townspeople have been irate with Patton ever since. Kimble is recognized by Pat from a wanted poster in his office. He privately tells Kimble that he has one month to live because he's dying from a congenital heart condition. Pat wants Kimble to keep him alive long enough to finish the motel he is working on; if Kimble refuses or flees, Pat will turn him in to the authorities.

After fleeing a police roadblock where he gets shot in the leg, Kimble hops on a truck headed toward Sacramento. He once again meets up with Sister Veronica (from the two-part episode Angels Travel On Lonely Roads of Season 1), who is now the principal of the St. Mary Magdalene School for girls. Kimble asks the nun to drive him to Tarleton, where the one-armed man supposedly works. Sister Veronica, who is suffering from a brain tumor, learns that a delinquent student has run away and is torn between driving after the girl or staying to help Kimble. Things get more complicated when Marie, a "bad girl" student, sees Kimble and calls the police.

At a California Angels baseball game, Kimble unwittingly witnesses a man walk away with a woman. Andy Newmark, the woman's father, summons Kimble, claiming the woman is his daughter and she has been kidnapped. Her abductors want a $200,000 ransom. When word leaks out, reporters surround the Newmark household and Kimble is unable to slip away. The kidnappers, a former baseball player and a friend, realize that Kimble witnessed them, so they plot to have Kimble deliver the ransom money so they can kill him.

Fritz Simpson is a college professor doing research on sleep deprivation; he is also a close friend of Kimble as he, Richard, wife-to-be Helen, and Fritz's wife Caroline were college pals. One of his patients is the one-armed man, Fred Johnson, who works as a groundskeeper at Wellington College under the alias Carl Stoker. Fritz contacts Kimble, who verifies that it is indeed Johnson. Fritz arranges for Stoker/Johnson to participate in his dream withdrawal experiments to try and extract a confession from him. Caroline, however, sees Kimble and calls Lt. Gerard, still bitter because as youths Fritz had loved Helen before her. Fritz and Kimble finally draw a recorded confession from Johnson -- until Gerard bursts into the experiment and a three-way chase ensues.
Guest Stars: William Windom as Fritz, Geraldine Brooks as Caroline, and Jill Janssen (David Janssen's sister) as a student.

Kimble becomes romantically involved with former recording star Gayle Martin, unaware that she knows his secret and the $10,000 reward for his capture. Gayle and her other lover, Alan Bartlet, are plotting to kill Alan's wealthy wife Norma, a former golf pro now confined to a wheelchair, and put the blame on Kimble so they can capture him and collect the reward money, as well as Norma's vast wealth.

After being arrested in a small Montana town for a minor loitering charge and resisting arrest, Kimble is put in jail next to a suspect in a race-related killing. The black deputy becomes determined to transport Kimble and the racist murderer to the state capital for arraignment, but they are ambushed by the killer's accomplices and are now forced to travel on foot through hostile territory.

Kimble is working at a cigar-making store owned by Jose Anza and becomes close friends with his son, Jimmy, who is threatened by three bullies. Kimble is shot in the leg after the police discover him, so Jimmy hides him from both his father and his uncle Miguel, a police officer determined to capture the fugitive.

Fleeing to an unnamed Central American country, Kimble contracts pneumonia. He seeks refuge at a local hospital where he is recognized by Dr. Howell, an American who is conducting research on meningitis. After Kimble recovers, Dr. Howell blackmails him into assisting with his research in exchange for protection from the local police. While working with Howell's assistant, Reina Morales, Kimble soon discovers that several of the patients are being unwittingly infected and sacrificed for Howell's research purposes. Meanwhile, a persistent police sergeant, Rodriguez, begins investigating Kimble's true identity. Though it is not mentioned which country Kimble is in, it is not Mexico -- the country is said to have provinces, not states.

Kimble travels to Washington, D.C. to meet lawyer Frank Hobart, who wrote a book titled Unjustly Convicted, which states that Kimble was convicted without the benefit of a fair trial due to the media circus influencing the judge and jury. Kimble wants Hobart to represent him while the lawyer tries to persuade the courts to re-open the Kimble murder case. Afterwards, Kimble finds himself tending to Unawa, an African ambassador who suddenly collapses in the street. The grateful ambassador shelters Kimble at his embassy, despite protests from the ambassador's wife, Davala, who learns Kimble's identity. Unawa believes in Kimble's innocence, but Davala offers no opinion; she simply believes that Kimble's presence in the embassy -- if it were established the ambassador deliberately shielded a convincted criminal from capture -- could cause an international incident that would end her husband's career. She contacts Gerard and the local police who surround the building, but cannot enter it due to the embassy being a part of foreign soil. Unawa falls into a coma after revealing to Kimble that he is dying from a brain tumour. Davala takes advantage of this to relocate the embassy so the police can move in and arrest Kimble.

Kimble, working as a truck driver out of Portland, Oregon, becomes romantically involved with radio dispatcher Barbara Wells, unaware that she is a convicted embezzler on loan through the state prison's work-release program. Distraught after her parole is denied for another six months, Barbara flees to a small, out-of-the-way resort in the wilds of Washington state where she knows Kimble (who is on the road awaiting a shipment) is staying. She wants to go to Canada with him, but soon enough the authorities are looking for AWOL prisoner Barbara... and for Kimble as well.

In the hills of Washington state, a young sculptor named Andrea hides Kimble from a deputy named Howe. When the lawman finds him, Kimble retreats deeper into the mountain, taking refuge in the home of hermit John Mallory, a former scholar who cut himself off from civilization 14 years earlier, and his only companions who are two vicious German Shepherd dogs. Despite being aware that Kimble is a fugitive, the hermit Mallory takes a liking to Kimble and forbids him to leave. Kimble is compelled to help the ailing Mallory as the deputy closes in on their location.

Guest Stars: Diane Baker as Jean Carlisle, Joseph Campanella as Captain Lee (Part 1), Michael Constantine as Arthur Howe (Part 1), Jacqueline Scott as Donna Taft, Richard Anderson as Leonard Taft, J.D. Cannon as Lloyd Chandler (Part 2), Louise Latham as Betsy Chandler (Part 2), Diane Brewster (uncredited) as Helen Kimble (Part 2).