Prof

Timothy Rutland Walsh

OBE
CitizenshipAustralian
OccupationResearcher
Known forNDM-1
Academic background
Alma materUniversity of Bristol; University of Tasmania
ThesisInducible β-lactamase expression in non-fastidious gram-negative bacilli (1995)
Academic work
Era2000s-present
DisciplineMicrobiology
Sub-disciplineAntibiotic resistance
InstitutionsOxford University; Cardiff University; University of Bristol

Timothy Rutland Walsh OBE is a professor working at the University of Oxford. He is a specialist in antimicrobial resistance. He is the Oxford Institute of Antimicrobial Research (IOI) Director of Biology. His work at IOI invlolves developing new antibiotics to use with animals, so that any antibiotic resistance developed in aminals would not affect humans. His IOI work also involves screening many chemicals to find new antimicrobial substances, and also to find those that inhibit antimicrobial resistance. Also he is invovled in documenting the large scale effects of antibiotic resistance in low to middle income countries, such as China, Pakistan and Tanzania.[1][2]

Early life

Timothy Walsh was born in England but migrated to Tasmania when he was a teenager. His father was a biologist and mother a chemistry teacher. He studied at the University of Tasmania and earned a degree in medical laboratory science. He then worked at the Royal Hobart Hospital in the lab as a microbiologist. He then undertook a master's degree in immunology and microbiology in Tasmania.[3]

Walsh continued his research by moving to the UK and completed a PhD at Bristol University in 1995. His research involved β-lactamases. [3]

Afterwards he worked at the UK Medical Research Council in the protein structure unit, and then later at the University of Bristol. In 2006 he started work at the Cardiff University as a professor with a title of chair in Medical Microbiology and Antibiotic Resistance.[3][3]

Discoveries

His research determined that a large proportion of ants, cockroaches, flies, moths and spiders were carrying extended spectrum cephalosporin and carbapenem resistant baccteria.[4]

Prof. Walsh was the discoverer of New Delhi metallo-beta-lactamase 1 NDM gene[3] and the mobilized colistin resistance gene. He was also the codiscovereer of the mobile tigecycline-resistance genes designated tet(X3) and tet(X4).[5]

The naming of New Delhi metallo-beta-lactamase 1 caused controversy due to the highlighting of New Delhi in the name of a gene.[6][7]

As a result of Walsh's findings, use of colistin in animals was banned in China in 2017.[8]

Qualifications

Walsh received a DSc from Bristol University in 2022.[9]

Prof Walsh received an OBE for services to microbiology and international development in the Queen's New Years Honours in 2020.[10]

Positions

Walsh is the principal investigator for Burden of Antibiotic Resistance in Neonates from Developing Societies (BARNARDS), a Gates Foundation project.[11]

References

  1. ↑ "Professor Timothy Rutland Walsh DSc OBE". www.biology.ox.ac.uk.
  2. ↑ Carvalho, M. J.; Sands, K.; Thomson, K.; Portal, E.; Mathias, J.; Milton, R.; Gillespie, D.; Dyer, C.; Akpulu, C.; Boostrom, I.; Hogan, P.; Saif, H.; Ferreira, A.; Nieto, M.; Hender, T.; Hood, K.; Andrews, R.; Watkins, W. J.; Hassan, B.; Chan, G.; Bekele, D.; Solomon, S.; Metaferia, G.; Basu, S.; Naha, S.; Sinha, A.; Chakravorty, P.; Mukherjee, S.; Iregbu, K.; Modibbo, F.; Uwaezuoke, S.; Audu, L.; Edwin, C. P.; Yusuf, A. H.; Adeleye, A.; Mukkadas, A. S.; Zahra, R.; Shirazi, H.; Muhammad, A.; Ullah, S. N.; Jan, M. H.; Akif, S.; Mazarati, J. B.; Rucogoza, A.; Gaju, L.; Mehtar, S.; Bulabula, A. N. H.; Whitelaw, A.; Roberts, L.; Walsh, T. R. (4 August 2022). "Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries". Nature Microbiology. 7 (9): 1337–1347. doi:10.1038/s41564-022-01184-y. ISSN 2058-5276. PMC 9417982. PMID 35927336.
  3. 1 2 3 4 5 Kirby, Tony (March 2012). "Timothy Walsh: introducing the world to NDM-1". The Lancet Infectious Diseases. 12 (3): 189. doi:10.1016/S1473-3099(12)70044-0. PMID 22361430.
  4. ↑ "New research provides compelling evidence of connection between AMR surgical-site infections and arthropods". Mirage News.
  5. ↑ He, Tao; Wang, Ran; Liu, Dejun; Walsh, Timothy R.; Zhang, Rong; Lv, Yuan; Ke, Yuebin; Ji, Quanjiang; Wei, Ruicheng; Liu, Zhihai; Shen, Yingbo; Wang, Gang; Sun, Lichang; Lei, Lei; Lv, Ziquan; Li, Yun; Pang, Maoda; Wang, Liyuan; Sun, Qiaoling; Fu, Yulin; Song, Huangwei; Hao, Yuxin; Shen, Zhangqi; Wang, Shaolin; Chen, Gongxiang; Wu, Congming; Shen, Jianzhong; Wang, Yang (27 May 2019). "Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans". Nature Microbiology. 4 (9): 1450–1456. doi:10.1038/s41564-019-0445-2. PMID 31133751. S2CID 256704595.
  6. ↑ Mohapatra, P. R. (2013). "Metallo-β-lactamase 1 - why blame New Delhi & India?". The Indian Journal of Medical Research. 137 (1): 213–215. PMC 3657891. PMID 23481076.
  7. ↑ Walsh, Timothy R; Toleman, Mark A; Sarma, Jayanta B; Irfan, Seema; Woodford, Neil; Livermore, David M (November 2010). "New Delhi metallo-β-lactamase 1 – Authors' reply". The Lancet Infectious Diseases. 10 (11): 752–754. doi:10.1016/S1473-3099(10)70245-0.
  8. ↑ Zhao, Qian; Li, Yiming; Tian, Yingxin; Shen, Yueyun; Wang, Shaolin; Zhang, Ying (10 February 2022). "Clinical Impact of Colistin Banning in Food Animal on mcr-1-Positive Enterobacteriaceae in Patients From Beijing, China, 2009–2019: A Long-Term Longitudinal Observational Study". Frontiers in Microbiology. 13. doi:10.3389/fmicb.2022.826624. PMID 35222338.
  9. ↑ Walsh, Timothy Rutland (2022). "DSc - Timothy Rutland Walsh". University of Bristol.
  10. ↑ Lane, Ellis (27 December 2019). "Gloucestershire's New Year's Honours list in full". GloucestershireLive. Retrieved 24 September 2023.
  11. ↑ Milton, Rebecca; Gillespie, David; Dyer, Calie; Taiyari, Khadijeh; Carvalho, Maria J; Thomson, Kathryn; Sands, Kirsty; Portal, Edward A R; Hood, Kerenza; Ferreira, Ana; et al. (May 2022). "Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: an international multisite prospective observational study". The Lancet Global Health. 10 (5): e661–e672. doi:10.1016/S2214-109X(22)00043-2. PMC 9023753. PMID 35427523.
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