| Transformer | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | tra | ||||||
| Alt. symbols | CG16724; Dmel\CG16724; Dmtra | ||||||
| Entrez | 39849 | ||||||
| RefSeq (mRNA) | NM_079390.3 | ||||||
| RefSeq (Prot) | NP_524114.1 | ||||||
| UniProt | P11596 | ||||||
| Other data | |||||||
| Chromosome | 3L: 16.58 - 16.58 Mb | ||||||
| |||||||
| Fruit fly transformer | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Transformer | ||||||||
| Pfam | PF06495 | ||||||||
| InterPro | IPR010519 | ||||||||
| |||||||||
Alternative splicing of dsx pre-mRNA. Tra2 is a transformer protein; the gene is involved in the regulation of sex determination in many insects.[1]
| Transformer-2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | tra2 | ||||||
| UniProt | P19018 | ||||||
| |||||||
Female-specific protein transformer is a protein that in Drosophila melanogaster is encoded by the tra gene. Unlike the related tra2 protein, it is only produced in females.
The transformer protein controls female somatic sexual differentiation.[2][3] The protein contains an RNA recognition motif. It controls the alternative splicing of the fly sex determination gene doublesex.[1]
References
- 1 2 Verhulst EC, van de Zande L, Beukeboom LW (August 2010). "Insect sex determination: it all evolves around transformer" (PDF). Current Opinion in Genetics & Development. 20 (4): 376–83. doi:10.1016/j.gde.2010.05.001. hdl:11370/2174764d-bd1b-4e1f-b142-90aced0c3e55. PMID 20570131. S2CID 205003182.
- ↑ Boggs RT, Gregor P, Idriss S, Belote JM, McKeown M (August 1987). "Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene". Cell. 50 (5): 739–47. doi:10.1016/0092-8674(87)90332-1. PMID 2441872. S2CID 33918630.
- ↑ Li H, Bingham PM (October 1991). "Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing". Cell. 67 (2): 335–42. doi:10.1016/0092-8674(91)90185-2. PMID 1655279. S2CID 20307555.
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