SUPT3H
Identifiers
AliasesSUPT3H, SPT3, SPT3L, SPT3 homolog, SAGA and STAGA complex component
External IDsOMIM: 602947 MGI: 1923723 HomoloGene: 121570 GeneCards: SUPT3H
Orthologs
SpeciesHumanMouse
Entrez

8464

109115

Ensembl

ENSG00000196284

ENSMUSG00000038954

UniProt

O75486

n/a

RefSeq (mRNA)

NM_178652
NM_001357320

RefSeq (protein)

n/a

Location (UCSC)Chr 6: 44.81 – 45.38 MbChr 17: 45.09 – 45.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.[5][6][7]

Interactions

Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,[8][9] TAF6L,[9] TADA3L,[9] TAF5L,[9] SF3B3,[9] SUPT7L,[9] Myc,[10] TAF9,[9] Transformation/transcription domain-associated protein,[9] TAF12,[9] TAF10,[8][9] TAF4[8] and DDB1.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196284 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038954 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. S2CID 18942972.
  6. Martinez E, Kundu TK, Fu J, Roeder RG (Sep 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry. 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987.
  7. "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)".
  8. 1 2 3 Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
  9. 1 2 3 4 5 6 7 8 9 10 11 Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
  10. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.

Further reading

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