| Combination of | |
|---|---|
| Trimethoprim | Dihydrofolate reductase inhibitor |
| Sulfadoxine | Sulfonamide antibiotic |
| Clinical data | |
| Trade names | Trimidox |
| Identifiers | |
| CAS Number | |
Trimethoprim/sulfadoxine, sold under the brand name Trimidox, is an antibacterial agent that is used in cattle and swine to prevent and treat infections by both gram-negative and gram-positive bacteria.[1]
Veterinary uses
Trimethoprim/sulfadoxine is used in the treatment of swine and cattle, including dairy cattle, beef cattle and veal.
In cattle, it is used to treat:
- Respiratory tract infections such as bovine pneumonia pasteurellosis (shipping fever)[1]
- Alimentary tract infections such as salmonellosis and both enteric and septicaemic colibacillosis[1]
- Other infections such as pododermatitis (foot rot) and septicaemias[1]
In swine, it is used to treat:
- Respiratory tract infections such as bacterial pneumonias[1]
- Alimentary tract infections such as post-weaning scours and colibacillosis[1]
- Other infections such as bacterial arthritis and mastitis-metritis-agalactia syndrome in sows.[1]
Contraindications
Trimethoprim/sulfadoxine is contraindicated in cattle or swine that show marked liver parenchymal damage or blood dyscrasias, or those with a history of sulfonamide sensitivity.[1]
Milk from an animal treated with trimethoprim/sulfadoxine must not be consumed for at least 96 hours following the most recent treatment; treated animals must not be slaughtered for use in food for at least ten days after the last treatment.[1]