Tromantadine
Skeletal formula
Clinical data
Trade namesViru-Merz
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Topical (gel)
ATC code
Legal status
Legal status
  • US: Not FDA-approved
  • OTC (RU)
Identifiers
  • N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.053.409
Chemical and physical data
FormulaC16H28N2O2
Molar mass280.412 g·mol−1
3D model (JSmol)
  • O=C(NC13CC2CC(CC(C1)C2)C3)COCCN(C)C
  • InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19) checkY
  • Key:UXQDWARBDDDTKG-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.[1][2]

Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.

Mechanism

Tromantadine inhibits the early and late events in the virus replication cycle.[3] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

References

  1. ↑ Ostheimer KE, Busch T, Görtelmeyer R, Hahn KD (September 1989). "Randomized double-blind trial of tromantadine versus aciclovir in recurrent herpes orofacialis". Arzneimittel-Forschung. 39 (9): 1152–1155. PMID 2686658.
  2. ↑ Diezel W, Michel G, Görtelmeyer R, Ostheimer KE (April 1993). "Efficacy of tromantadine and aciclovir in the topical treatment of recurrent herpes orofacialis. Comparison in a clinical trial". Arzneimittel-Forschung. 43 (4): 491–496. PMID 8494582.
  3. ↑ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrobial Agents and Chemotherapy. 22 (6): 1031–1036. doi:10.1128/aac.22.6.1031. PMC 185716. PMID 6297383.
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