Urs Jenal
Urs Jenal (2015)
NationalitySwiss
Scientific career
FieldsExperimental Biologist
InstitutionsETH Zurich, Stanford University, Biozentrum University of Basel

Urs Jenal is a Swiss Microbiologist and Professor at the Biozentrum University of Basel, Switzerland.

Life

Urs Jenal studied Experimental Biology at the Swiss Federal Institute of Technology (ETH) Zurich and received his PhD from there in 1991. Subsequently, he completed postdoctoral research at the ETH Zurich and at Stanford University, USA. Since 1996, Jenal has taught and conducted research at the Biozentrum University of Basel; first as an Assistant Professor and since 2002 as a Professor of Molecular Microbiology.[1]

Work

The research of Urs Jenal explores the molecular basis of signal transduction[2] controlling the growth, development and behavior of bacteria.[3] Jenal received international acclaim through his discovery of a new signalling network, which is based on the cyclic di-nucleotide (c-di-GMP)[4] and which coordinates bacterial surface colonization and virulence[5] during chronic bacterial infections.[6] With the model bacterium Caulobacter crescentus, Jenal discovered that c-di-GMP controls the transition from motile bacteria[7] to a sedentary biofilm-forming structure[8] and how this process is coordinated with the replication cycle of these cells.[9] Jenal’s most recent work has investigated the importance of signalling and metabolism for chronic lung infections caused by Pseudomonas aeruginosa in patients with cystic fibrosis.[10]

Awards and honors

References

  1. ↑ Curriculum Vitae Biozentrum.unibas.ch Retrieved 2022-01-31
  2. ↑ Jenal, Urs (April 2000). "Signal transduction mechanisms in Caulobacter crescentus development and cell cycle control". FEMS Microbiol. Rev. 24 (2): 177–191. doi:10.1016/S0168-6445(99)00035-2. PMID 10717313. S2CID 21361399.
  3. ↑ Laventie, Benoît-Joseph; Jenal, Urs (8 September 2020). "Surface Sensing and Adaptation in Bacteria" (PDF). Annu Rev Microbiol. 74: 735–760. doi:10.1146/annurev-micro-012120-063427. PMID 32905753. S2CID 221622525.
  4. ↑ Jenal, Urs; Reinders, Alberto; Lori, Christian (6 February 2017). "Cyclic di-GMP: second messenger extraordinaire" (PDF). Nature Reviews Microbiology. 15 (5): 271–284. doi:10.1038/nrmicro.2016.190. PMID 28163311. S2CID 23220964.
  5. ↑ Laventie, Benoît-Joseph; Sangermani, Matteo; Estermann, Fabienne; Manfredi, Pablo; Planes, Rémi; Hug, Isabelle; Jaeger, Tina; Meunier, Etienne; Broz, Petr; Jenal, Urs (20 December 2018). "A surface-induced asymmetric program promotes tissue colonization by Pseudomonas aeruginosa". Cell Host & Microbe. 25 (1): 140–152. doi:10.1016/j.chom.2018.11.008. PMID 30581112. S2CID 58637629.
  6. ↑ Broder, Ursula N.; Jaeger, Tina; Jenal, Urs (24 October 2016). "LadS is a calcium-responsive kinase that induces acute-to-chronic virulence switch in Pseudomonas aeruginosa". Nature Microbiology. 2: 16184. doi:10.1038/nmicrobiol.2016.184. PMID 27775685. S2CID 6700536.
  7. ↑ Kaczmarczyk, Andreas; Hempel, Antje M.; von Arx, Christoph; Böhm, Raphael; Dubey, Badri N.; Nesper, Jutta; Schirmer, Tilman; Hiller, Sebastian; Jenal, Urs (10 February 2020). "Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter". Nature Communications. 12 (1): 816. Bibcode:2020NatCo..11..816K. doi:10.1038/s41467-020-14585-6. PMC 7010744. PMID 32041947.
  8. ↑ Hug, Isabelle; Deshpande, Siddharth; Sprecher, Kathrin S.; Pfohl, Thomas; Jenal, Urs (27 October 2017). "Second messenger-mediated tactile response by a bacterial rotary motor" (PDF). Science. 358 (6362): 531–534. Bibcode:2017Sci...358..531H. doi:10.1126/science.aan5353. PMID 29074777. S2CID 4871457.
  9. ↑ Lori, Christian; Ozaki, Shogo; Steiner, Samuel; Böhm, Raphael; Abel, Sören; Dubey, Badri N.; Schirmer, Tilman; Hiller, Sebastian; Jenal, Urs (9 July 2015). "Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication" (PDF). Nature. 523 (7559): 236–239. Bibcode:2015Natur.523..236L. doi:10.1038/nature14473. PMID 25945741. S2CID 205243846.
  10. ↑ Santi, Isabella; Manfredi, Pablo; Maffei, Enea; Egli, Adrian; Jenal, Urs (9 February 2021). "Evolution of antibiotic tolerance shapes resistance development in chronic Pseudomonas aeruginosa infections". mBio. 12 (1). doi:10.1128/mBio.03482-20. PMC 7885114. PMID 33563834.
  11. ↑ "American Academy of Microbiology (AAM), Fellows Elected in 2011". Archived from the original on 2013-07-24. Retrieved 2013-08-13.
  12. ↑ Meet FEMS Expert fems-microbiology.org Retrieved 2022-01-31
  13. ↑ EAM members fems-microbiology.org Retrieved 2022-01-31
  14. ↑ Datahub of ERC funded projects erc.easme-web.eu Retrieved 2022-01-31
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