WFIKKN2

WFIKKN2
Identifiers
Aliases	WFIKKN2, GASP-1, WFDC20B, WFIKKNRP, hGASP-1, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
External IDs	OMIM: 610895 MGI: 2669209 HomoloGene: 35284 GeneCards: WFIKKN2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,842,353 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,136,831 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; left adrenal gland; ; cerebellar hemisphere; ; tibia; ; gastrocnemius muscle; ; tibial nerve; ; pituitary gland; ; anterior pituitary; ; ganglionic eminence; ; testicle;
	Top expressed in
	otolith organ; ; utricle; ; retinal pigment epithelium; ; thymus; ; temporal muscle; ; lens; ; knee joint; ; muscle tissue; ; habenula; ; vas deferens;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; protein binding; receptor antagonist activity; transforming growth factor beta binding;
Cellular component	extracellular region; extracellular space;
Biological process	skeletal system development; negative regulation of DNA binding; roof of mouth development; negative regulation of peptidase activity; negative regulation of protein binding; negative regulation of endopeptidase activity; transforming growth factor beta receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; extracellular negative regulation of signal transduction; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	124857
	278507
	ENSG00000173714
	ENSMUSG00000044177
	Q8TEU8
	Q7TQN3
	NM_175575; NM_001330341
	NM_181819
	NP_001317270; NP_783165
	NP_861540
	Wikidata
View/Edit Human	View/Edit Mouse

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 is a protein that in humans is encoded by the WFIKKN2 gene.^[5]

Function

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173714 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044177 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2".

Szláma G, Kondás K, Trexler M, Patthy L (December 2010). "WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity". The FEBS Journal. 277 (24): 5040–50. doi:10.1111/j.1742-4658.2010.07909.x. PMID 21054789. S2CID 45602047.
Hill JJ, Qiu Y, Hewick RM, Wolfman NM (June 2003). "Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains". Molecular Endocrinology. 17 (6): 1144–54. doi:10.1210/me.2002-0366. PMID 12595574.
Kondás K, Szláma G, Trexler M, Patthy L (August 2008). "Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11". The Journal of Biological Chemistry. 283 (35): 23677–84. doi:10.1074/jbc.M803025200. PMC 3259755. PMID 18596030.
Nagy A, Trexler M, Patthy L (May 2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". European Journal of Biochemistry. 270 (9): 2101–7. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070.
Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET (May 2012). "Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women". Journal of Strength and Conditioning Research. 26 (5): 1374–82. doi:10.1519/JSC.0b013e318251083f. PMID 22395277. S2CID 12311653.
Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K (April 2010). "Effects of oral creatine and resistance training on serum myostatin and GASP-1". Molecular and Cellular Endocrinology. 317 (1–2): 25–30. doi:10.1016/j.mce.2009.12.019. PMID 20026378. S2CID 25180090.
Trexler M, Bányai L, Patthy L (January 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biological Chemistry. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817. S2CID 37069938.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173714 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044177 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2".

[1]

[2]

[3]

[4]

[5]

Function

See also

References

Further reading