WTAP
Identifiers
AliasesWTAP, Mum2, Wilms tumor 1 associated protein, WT1 associated protein
External IDsOMIM: 605442 MGI: 1926395 HomoloGene: 68422 GeneCards: WTAP
Orthologs
SpeciesHumanMouse
Entrez

9589

60532

Ensembl

ENSG00000146457

ENSMUSG00000060475

UniProt

Q15007

Q9ER69

RefSeq (mRNA)

NM_001113532
NM_001113533
NM_175394
NM_001379058

RefSeq (protein)

NP_001107004
NP_001107005
NP_780603
NP_001365987

Location (UCSC)Chr 6: 159.73 – 159.76 MbChr 17: 13.19 – 13.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.[5][6][7]

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.[7]

Interactions

WTAP has been shown to interact with WT1.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000146457 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060475 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  6. 1 2 Little NA, Hastie ND, Davies RC (Oct 2000). "Identification of WTAP, a novel Wilms' tumour 1-associating protein". Hum Mol Genet. 9 (15): 2231–9. doi:10.1093/oxfordjournals.hmg.a018914. PMID 11001926.
  7. 1 2 "Entrez Gene: WTAP Wilms tumor 1 associated protein".

Further reading


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