Game 1

A raucous, sold-out Metrodome met the Cardinals on October 17, stunning the visitors with crowd noise that could exceed 110 decibels SPL. The Cardinals struggled defensively, with outfielder Willie McGee losing sight of pop flies against the Metrodome's white roof in the fourth and eighth innings, and infielder Tom Lawless committing an infield error in the sixth inning. None of those miscues, however, contributed to Twins runs. The Twins' aggressive play further compounded the problems of the Cards, and the game ended as a 10–1 blowout. Starting pitcher Frankie "Sweet Music" Viola had little trouble with the Cardinals' potent lineup. For the Twins, Dan Gladden hit a grand slam and totaled five RBIs, capping off a seven-run fourth inning, with Steve Lombardozzi adding a two-run homer, while Kent Hrbek had two RBIs.

Frank Viola was scheduled to be best man at his brother's wedding, but had to cancel when the Twins reached the World Series as it fell on the same night as Game 1, in which he was scheduled as starter. ABC showed clips of the wedding throughout the game's broadcast.

Coincidentally, the song "U Got The Look" peaked in popularity (#2 on the Billboard singles chart) on this date. The song was written and performed by Prince (a Minneapolis native) and contains the line "boy versus girl in the World Series of love".

Game 2

While improving on their Game One performance, the Cards were again unable to hold the Twins offense and fell behind 7–0 before beginning to rally. The Cards' total of nine hits was just one short of the Twins but they managed only one double, against three doubles and two home runs hit by Minnesota. Gary Gaetti hit a homer in the second inning. The Twins broke the game open in the fourth, scoring six runs resulting in starter Danny Cox being pulled from the game. The final score was 8–4. Randy Bush and Tim Laudner each came through with a pair of two-run-scoring hits in the fourth, with Laudner's being a home run and Bush's being a double. Bert Blyleven pitched seven innings of two-run baseball for the win.

John Tudor allowed one run in Game 3 and earned the win.

Game 3

Traveling down the Mississippi, to the open air of Busch Stadium, Game 3 saw a tense pitching duel between Twins starter Les Straker and John Tudor of the Cardinals. This match-up was also notable for Straker being the first Venezuelan to pitch in a World Series game.

After five scoreless innings by both teams, the Twins broke through in the top of the sixth inning. Greg Gagne walked to lead off the inning, and Kirby Puckett walked to move Gagne into scoring position. Tom Brunansky's RBI single looked like all the offense the game would see. But, in the bottom of the seventh, Juan Berenguer, in relief of Straker, surrendered leadoff back-to-back singles to Jose Oquendo and Tony Peña. Terry Pendleton sacrificed the runners to second and third, and Vince Coleman slammed a two-run double to give the Cards a 2–1 lead. Ozzie Smith followed by singling in Coleman for the final run, and Todd Worrell closed out saving the win for Tudor.

Game 4

In Game 4, the Twins scored first on Greg Gagne’s home run, but the Cardinals tied it on a Jim Lindeman RBI single. Tom Lawless hit a three-run homer in the fourth off Viola (only his second Major League homer after going 2 for 25 during the regular season), one of Viola's five earned runs in the game and six runs in the fourth. The Cards, however, weren't done scoring; Dan Schatzeder allowed another RBI single to Lindeman and a two-run double to Willie McGee. Joe Niekro and George Frazier shut the Redbirds out the rest of the game. Bob Forsch got the win with 2+2⁄3 innings of one run relief. Starter Greg Mathews aggravated a quadriceps injury in the fourth inning (the injury went back to Game 5 of the NLCS), had to be removed from the game and was unable to play for the rest of the series. Ken Dayley got the save.

Just prior to Game 4, Reggie Jackson, who was working as a field reporter for ABC's coverage of the 1987 World Series, admitted that he didn't know who Tom Lawless was.

Danny Cox allowed no runs on the mound and was credited with the win in Game 5.

Game 5

Game 5 was a much closer contest, with the Cardinals coming out victorious by a score of 4–2. Curt Ford hit a two-run single in the sixth, breaking a scoreless pitcher's duel between Danny Cox and Bert Blyleven. By the end of the seventh, the Cards were up 4–0. The Twins scored two in the eighth on a triple by Gary Gaetti off reliever Todd Worrell to made a game of it, but eventually relinquished the save to him as Gaetti failed to score. The Cardinals stole five bases in Game 5, the most for any team since the 1907 Chicago Cubs.

Game 6

Cardinals Second Baseman Tommy Herr.

The Series returned to the Metrodome with the Twins facing elimination (a position they would find themselves in four years later against the Atlanta Braves). ABC allowed the game to be played at 3 p.m. CT (4 p.m. ET) on Saturday afternoon – the only day game of the series, and the last World Series game to date to be played in the daytime (although as the game was played in the Metrodome, the game took place under artificial lighting).

The Cardinals drew first blood off Les Straker on a Tommy Herr home run in the first, and the Twins countered with two in their half of the first on RBI singles by Kirby Puckett and Don Baylor. The Cardinals soon tied it in the second on a Jose Oquendo RBI single.

Twins First Baseman Kent Hrbek hit a grand slam during Game 6.

In the fourth, the Cards chased Straker when Dan Driessen led off with a double to right and went to third on a Willie McGee single. McGee took second on the attempted throw home by center fielder Kirby Puckett. Terry Pendleton followed by singling home Driessen and Oquendo hit a sacrifice fly to make it 4–2. Another run scored for the Cards in the fifth when lefty Dan Schatzeder walked Ozzie Smith. Smith went to second on a groundout, to third on a flyout, and scored on another McGee single.

In the bottom of the fifth, however, the Twins began to claw their way back against John Tudor. Puckett led off with a single and was doubled in by Gary Gaetti. Benefitting from use of the designated hitter in their home ballpark, the Twins then tied it on a mammoth home run by their DH, Don Baylor. After Tom Brunansky followed with a single, the Twins took the lead for good when Steve Lombardozzi singled him in with two out on a close play at the plate.

The Twins then blew the game open in the sixth. Greg Gagne led off with an infield single and Puckett walked. A passed ball by Tony Peña advanced the runners. With first base open and one out, Cards veteran Bob Forsch intentionally walked Baylor to load the bases. Baylor had played only 20 regular season games with the Twins after being traded from Boston and Tim McCarver in the ABC broadcast booth argued that he should be pitched to rather than walked, despite the home run in the previous inning. Both Jim Palmer and Al Michaels agreed, as Palmer didn't like the idea of loading the bases with the risk of giving up multiple runs, and Michaels pointed out that left-hander Ken Dayley might have to be brought in earlier than normal.^[10] After Brunansky popped out, Dayley was indeed brought in to face the lefty-hitting Kent Hrbek. Hrbek finally broke out of his slump and hit a grand slam to the deepest part of center field.

Brunansky drove in the final run in the eighth and the Twins had staved off defeat. This was the last day game in World Series history to date.

Game 7

Game 7 forced a National Football League game between the Denver Broncos and the Minnesota Vikings, originally scheduled for that afternoon at the Metrodome, to be played the following night (also on ABC).

Joe Magrane of the St. Louis Cardinals became only the sixth rookie pitcher to start the seventh game of a World Series.^[11] He also is the only pitcher in World Series history to start Games 1 and 7 of a World Series without any starts in between, as the Cardinals' Game 4 starter, Greg Mathews, had had to be removed early due to an injury and was unavailable for the remainder of the Series. Magrane had actually started the 1987 season pitching for the Cardinals Triple-A team, the Louisville Redbirds.

In the second, the Cardinals looked poised to send Frank Viola to an early shower. Three straight no-out singles by Jim Lindeman, Willie McGee, and Tony Peña plated the first run. Viola settled down to retire the next two hitters, but then Steve Lake singled in McGee for a 2–0 lead. Viola settled into a groove, however, and allowed only two more hits and no runs in eight strong innings.

Willie McGee was the final out in the series.

The Twins came back in their half of the second on a Steve Lombardozzi RBI single, but not before a missed call at home plate by umpire Dave Phillips had already cost the Twins a run. Twins DH Don Baylor reached base on a hit-by-pitch by Magrane to lead off the inning and Tom Brunansky singled him to second. With one out, Tim Laudner singled to left and Baylor was called out at home on a throw from Vince Coleman in left, while replays clearly showed Baylor was safe. Lombardozzi then singled in Brunansky.

In the fifth, the Twins tied the score when Greg Gagne reached on an infield hit and Kirby Puckett drove him in with a double. Incidentally, replays showed Gagne to be out on his infield hit, thus this run served to counteract the run the Twins lost in the second on the missed call on Baylor at the plate. The Twins seemed on the verge of taking the lead when Gary Gaetti followed Puckett with a walk and went to second when Puckett was thrown out by Lake trying to advance to third on a wild pitch that was deflected when it hit the home plate umpire in the face-mask. Baylor followed with a single to left, but Coleman threw out Gaetti at the plate in a violent collision with Lake. Coleman became the first outfielder to throw two runners out at the plate in one World Series game.

The sixth inning proved to be controversial. In the top of the sixth, Tom Herr had hit a single with one out. With Jim Lindeman at bat, the third missed call of the game would occur. On a 3-2 count, Herr would get caught in a rundown and Lombardozzi ran him back to first where Kent Hrbek was standing off the bag near the basepath. Lombardozzi tossed the ball towards Hrbek and the ball sailed past him but into the glove of Viola behind the bag. Viola had come over to take part in the rundown. Herr was hindered by Hrbek returning to the bag, but clearly reached the bag safely before Viola tagged him. However, first base umpire Lee Weyer called Herr out. Weyer's view was blocked by Kent Hrbek and, according to the broadcast crew, Viola made the tag late and Hrbek should have been called for interference. Had this been called, Herr would have been safe, awarded second base, and the Cardinals would have had a runner at second with one out. It was the third missed call of the game for the normally highly regarded Weyer—often considered one of the best umpires in baseball. On the next pitch, Lindeman flied out to right field to end the 6th inning.^[12] The Twins then took the lead in the bottom of the inning, off Danny Cox, who had relieved Magrane the previous inning. Cox walked Brunansky and Hrbek to lead off, and was replaced by Todd Worrell. As Cox was leaving, he got into an argument with home plate umpire Dave Phillips and was ejected as he was leaving the field. As of 2020, Cox is the last non-manager to be ejected from a World Series game. After retiring the first batter he faced, Worrell walked pinch-hitter Roy Smalley and struck out Dan Gladden for the second out. The next batter, Gagne, reached first on an infield hit as Brunansky scored the go-ahead run.

Jeff Reardon pitched a scoreless ninth inning to give the Twins their first world championship.

The Twins' final run came in the eighth on an RBI double by Dan Gladden off Worrell, who stayed in the rest of the game for the Cardinals. Jeff Reardon retired the side in the ninth to give Minnesota their first World Series victory.

With the victory, Tom Kelly became, at 37, the third youngest manager to win a World Series. Only John McGraw, who won the 1905 World Series at 32, and Frank Chance, who won the 1907 World Series at 30, are younger.