AMPD2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAMPD2, PCH9, SPG63, adenosine monophosphate deaminase 2
External IDsOMIM: 102771 MGI: 88016 HomoloGene: 2979 GeneCards: AMPD2
Orthologs
SpeciesHumanMouse
Entrez

271

109674

Ensembl

ENSG00000116337

ENSMUSG00000027889

UniProt

Q01433

Q9DBT5

RefSeq (mRNA)

NM_001289719
NM_001289720
NM_028779
NM_001346665

RefSeq (protein)

NP_001276648
NP_001276649
NP_001333594
NP_083055

Location (UCSC)Chr 1: 109.62 – 109.63 MbChr 3: 107.98 – 107.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AMP deaminase 2 is an enzyme that in humans is encoded by the AMPD2 gene.[5][6]

High AMPD2 expression levels correlate with poor patient outcome and a proliferative tumor phenotype in undifferentiated pleomorphic sarcoma (UPS). [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000116337 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027889 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mahnke-Zizelman DK, Sabina RL (Nov 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons". J Biol Chem. 267 (29): 20866–77. doi:10.1016/S0021-9258(19)36768-7. PMID 1400401.
  6. "Entrez Gene: AMPD2 adenosine monophosphate deaminase 2 (isoform L)".
  7. Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, et al. (September 2018). "Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma". International Journal of Cancer. 144 (4): 859–867. doi:10.1002/ijc.31903. PMID 30267407.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.