In 19th century Amherst, Massachusetts, a young Emily Dickinson is tired of her family's attempts to find her a suitor. The latest is a friend of hers, George, who agrees to publish one of Emily's poems. Emily then finds out that her brother Austin proposed to her best friend, Sue. Austin tells his parents his plans to move himself and Sue to Detroit, however his dad wants him to remain in Amherst. Afterwards, Emily and Sue meet and Emily asks Sue to always love her more than Austin and they kiss. George then tells Emily that her poem will be published in the next edition of the magazine, but Emily is afraid of her father's reaction. At dinner, Emily's father announces he plans to run for Congress, Austin announces he and Sue will remain in Amherst, and Emily tells her family about her poem being published. At the latter, Emily's father yells at her about ruining the family name. In her mind, Emily meets with Death and discusses her poems. That night, Emily's father talks about how he doesn't want to lose her and asks her not to marry and move away.

Emily and Sue lie in bed and discuss the idea of running away together. Emily discovers a lecturer is due to give a presentation on volcanoes but her father is against women getting a higher education. Later, Emily's mother is angry at her husband's decision to get a maid and reveals she feels useless. While shopping for dresses with her sister Vinnie, Emily accidentally spills that Sue got engaged. Afterwards, Emily and Sue decide to dress as men and sneak into the lecture themselves. At the college, George spots them, but agrees to keep their secret. However, partway through the lecture, Emily accidentally gives away that they are there. Her father is angry to discover Emily's actions and tells her to stop her antics. Emily's mother then accuses her of being selfish and not thinking of her father. Emily then asks the maid, Maggie, to teach her to make bread. That night, Emily tells Sue she feels trapped, like the people in Pompeii. Sue then tells her she knows what volcanoes feel like and they proceed to have sex.

Emily awakens after having a nightmare about losing Sue. Meanwhile, her parents go to Boston for the night and the kids decide to throw a party. Sue is hesitant about announcing her and Austin's engagement because of her lack of money, but Austin insists on paying all her debts. Vinnie's crush, Joseph, attends, as well as Jane, a former classmate of Emily's who's interested in Austin. George brings opium to the party and Emily shares it with the guests. George asks Emily to dance and talks about marrying Emily, but she tells him to marry a normal girl and they kiss before she runs away with stomach pains. Austin then announces his engagement to Sue before she runs after Emily, who reveals the pains were period pains. Jane reveals her feelings for Austin and questions his marriage to Sue because of Sue and Emily's relationship. Austin walks in on Emily and Sue kissing and Sue reveals she feels suffocated by both of them and intends to go to Boston.

With Sue gone to Boston, Emily and Austin are distraught. The town plans to build railroads through Amherst and Emily discovers that her favorite tree is going to be chopped down. After reading Walden, she and George seek out Henry David Thoreau for help. Emily is disappointed to find that he is uninterested in her cause, but her father nevertheless decides to protect her tree on her behalf.

George asks Edward's permission for Emily's hand in marriage and is disappointed when Edward seems to suggest that George is too lenient with Emily. As Emily prepares to act out Othello with her Shakespeare club, George tries to strongarm her into behaving more obediently, first by attempting to censor the play and later by refusing to let Henry, one of the Dickinson's hired hands who is Black, play the title role. Though George later tries to explain his actions, Emily is angered and rejects his marriage proposal outright.

The entire family believes that Emily is on her deathbed, leading both her father and mother to issue gruesome confessions. However, Emily is only feigning sickness in order to stay in her room to read and write poetry. Leaving her room in search of a book she meets her father's clerk, Ben Newton, who is also an avid fan of poetry. After finishing her poem and giving it to Ben, Emily pretends to make a miraculous recovery. She is surprised to encounter Sue, who returned after hearing Emily was on her deathbed. Emily urges Sue to go forward with her marriage to Austin. Lavinia hires an artist to paint a portrait of her. When she is displeased with the results she makes her own attempts to sketch herself.

Edward prepares for election day and is surprised when his supposedly safe seat Congressional seat becomes embroiled in an unexpectedly close race. Ben urges Emily to enter a local poetry contest but Emily refuses, knowing that doing so will embarrass her father. As a compromise, Emily asks Austin to submit "Nobody knows this little Rose" under his name. He does so and wins the contest. Edward realizes that the poem is Emily's and the two have a violent confrontation. Edward finally wins his seat but his entire family is too depressed and angry to celebrate his win.

Edward is gone for Christmas and the Dickinsons host a dinner party. Depressed by Edward's departure, Emily's mother takes to her bed leaving the children to act as hosts. Emily invites Ben, and Sue is surprised and jealous as Emily takes up domestic work in order to impress him. On Christmas morning Emily is surprised to learn that her father is building her a conservatory so that she can enjoy flowers year round.

Emily makes plans to go see a solar eclipse with Ben, who is very sick. During the eclipse the two "anti-marry" each other, promising to remain unwed for as long as they live. When his coughing grows worse Emily nurses him at the Dickinson family home and is disturbed when he begins to hallucinate. Sue is fitted for her wedding dress and discovers she is pregnant, much to her chagrin. Lavinia gives Joseph a nude sketch of herself.

Austin and Sue's marriage day arrives. Emily is still in mourning over Ben's death but tries to make Sue's wedding day special by writing her the love poem "One Sister have I in our house" and gathering a bouquet for her. Her actions reignite Austin's jealousy, and he bans her from the wedding and tells the family that it was Emily who decided not to come. George leaves town to seek his fortune in California and offers to take Emily with him, but she refuses citing her desire to remain with Sue. Edward finally returns.

Emily experiences hallucinations of a man who identifies himself as Nobody and struggles with her vision though she is more inspired than ever. The Dickinsons struggle with their finances as Emily's father tries to support Austin and Sue's lavish spending. Sue, after suffering through a miscarriage, loses herself in becoming a well-to-do influencer. Hoping to help Emily be published she introduces her to editor Samuel Bowles. When Sue calls on Emily to recite a poem for Bowles, she hallucinates 'Nobody' instead and is unable to do so. Bowles is not put off and is instead intrigued.

After coming in second in the baking contest the previous year, Emily is obsessed with winning the Amherst Cattle Show Baking Contest. After she wins she learns her recipe will be published in the newspaper. Sue uses the win to push Emily further towards the publication of her poems. Samuel Bowles and Emily start an intriguing friendship and she shares a poem with him. Austin, unaware of Sue's previous miscarriage, asks her to consider having a child with him.

Conflicted over whether to publish or not Emily has a seance and then hallucinates once more over the man who calls himself 'Nobody'. She makes a final decision over whether to publish or not. To fix their money problems Emily's father has his wealthy orphaned nieces come to live with them, much to his wife's chagrin.

Emily fears she may have lost her artistic vision and become overreliant on Samuel Bowles' opinion of her work. Lavinia is pressured into accepting an offer of marriage from Ship after an elaborate proposal. Austin, desperate to be a father, adopts the Newton girls, much to Sue's displeasure.

As Emily prepares for publication she learns that Samuel has a reputation for seducing the women he publishes and that everyone believes they have been intimate. Austin helps Henry have meetings in his barn for his group of abolitionists and brings them a printing press. Emily writes to Sam's wife, Mary. Lavinia seduces Ship to prove that she can be as crazy as Lola Montez.

The Dickinsons attend the opera where Emily, nursing a budding crush on Samuel, is excited to end up in his private box upon Sue's suggestion. However her dreams are dashed when Samuel confronts her with the letter she wrote his wife. Emily meets Adelaide backstage and tells her that she wants to be famous but is taken aback when Adelaide warns her about what that could mean.

The Dickinson women along with Aunt Lavinia head to a spa where Emily has a good moment with her mother. Emily frets about not being published but Sam assures her that he is only waiting for the right time to make her poem front page. She then gives him all of her poems. Austin is frustrated with Sue and finds comfort with Jane. Betty worries about her family as Henry's writing brought forth death threats from the South.

Emily's poem, "I taste a liquor never brewed", is finally published in The Springfield Republican. However she realizes that she's invisible and spends the day spying on people's reactions to her work. Depressed with what she finds, Emily skips Sue's salon celebrating her publication and instead finds comfort witnessing Henry's celebration of his efforts with the abolitionist paper, The Constellation. Later, returning to Sue and Austin's home she discovers Sue's affair with Sam.

Sue goes to visit her old friend Mary Bowles, Sam's wife. Austin holds a tea party in the meantime, gathering his friends for one last hurrah as rumors of a civil war begin. After the publication of her poem Emily finally decides to make herself known and is disturbed when she meets one of Austin's guests. Austin is upset about Sue and Emily comforts him.

Emily tries to retrieve her poems from Sam but hits a snag when she finds out he is determined to publish them and make her a literary star. Maggie manages to steal them back for her. Jane's child is christened and Austin is the godfather. Ship wants to move to New Orleans and Lavinia breaks up with him since she does not want to move south when there will be a civil war soon. Sue returns from her visit to Mary Bowles and with new clarity makes a confession to Emily.

As the civil war rages on the Dickinson family is devastated by the death of their maternal aunt Lavinia. Emily however is inspired by her aunt's death and pledges to take better care of her family. However an embittered Austin has drawn away from his family and become a drunkard and a playboy despite the fact that Sue is heavily pregnant. Edward has a heart attack.

In the wake of their father's heart attack, all the Dickinson children have different reactions with Lavinia and Austin questioning the control he has exercised over their lives. Lavinia is unhappy with her self imposed spinsterhood. Sue goes into labor and Emily, her mother and Maggie help to midwife the child into the world. Jane tells Austin she is marrying a wealthy man and moving to Vietnam.

Determined to heal the nation, Emily and Lavinia host a sewing circle to support the troops with help from Amherst's finest seamstress, Betty. Sue has a difficult time with the baby and wants Emily. Edward harbors no ill will towards Austin but Austin refuses to reconcile. Emily writes to Thomas Wentworth Higginson.

Emily reads the works of Walt Whitman and contemplates what it means to participate fully in the world. Henry reaches the war in the South and is placed with a group of Gullah soldiers where his job is to teach them to read and write. He is shocked at their extremely poor treatment.

For Edward's birthday, Emily organizes a sing-a-long with members of her family with Sue being surprisingly willing to go even though Austin will not. Emily is thrilled when Austin makes a surprise appearance but is crestfallen when Austin reveals he plans to split business ties with his father and divorce Sue. Meanwhile Sue becomes upset when she learns that despite Emily swearing that she is the only opinion that matters to her, she has been secretly reaching out to outside editors.

Edward receives an offer to be on the board of an insane asylum. Emily, Lavinia, and their mother go with him on a tour to support him but Mrs. Dickinson becomes terrified that due to her ongoing grief over the death of her sister, Edward plans to commit her. Surprisingly during the tour Edward learns that the head of the asylum wants to commit Emily. Meanwhile still estranged from the rest of the Dickinsons, Austin and Sue manage to reconcile and achieve some peace in their unconventional marriage by getting rid of gender roles in parenting.

After a clash with Sue, Emily wishes she could escape from this troubled time altogether. She glimpses into the 20th century and is shocked by the changes. She learns that Vinnie publishes her poems after her death from Sylvia Plath. Henry pleads with Higginson to arm the soldiers in the face of an advancing confederate army. Austin struggles with a man's responsibility in wartime and considers draft dodging to take care of his son.

On the day of a Frazer's memorial, Emily struggles to reunite with Austin. Her efforts to keep her family's hope alive reach a breaking point when she learns that her father plans on leaving everything to Austin despite what happened between them since he does not believe women should be independent. Sue gives an anonymous submission to the Union Army Newsletter. Emily descends into a personal inferno.

Emily takes steps to ensure that her family won't repeat their past mistakes and reconciles with Austin. Her mother comes to terms with Aunt Lavinia's death. The Massachusetts Republican Party nominates Edward for lieutenant governor. Higginson promotes Henry to Sergeant and takes a break from war. The Amherst gang gathers for a fond farewell. Emily reads out her published poem submitted by Sue.

Series finale. Emily asks Betty to help her design a new dress. Austin and Sue reconcile with Edward and they decide to work on a case together. They name their baby after him. The Dickinson family is surprised by an unexpected guest. Higginson informs Betty about Henry's whereabouts and returns his diary. Emily sees no need to leave her room.