HLA-A23
(MHC Class I, A cell surface antigen)
HLA-A23
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*2301, β2-microglobulin
Older namesHL-A9
Subtypes
Subtype
allele
Available structures
A23 *2301
Alleles link-out to IMGT/HLA database at EBI

HLA-A23 (A23) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α23 subset of HLA-A α-chains. For A23, the alpha, "A", chain are encoded by the HLA-A*23 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2301. A23 and A*23 are almost synonymous in meaning. A23 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A24.

A23 is common in Africa and regions of the Middle East, Mediterranean, and India than Europe, East Asia or the Americas.

Serotype

A23 recognition of some HLA A*23 gene products[2]
A*23 A23 A24 Sample
allele % % size (N)
*23019515119

Allele

HLA A*2301 frequencies
Study populationFreq.
 (in %)[3]
Mali Bandiagara22.8
Cameroon Yaounde18.7
Senegal Niokholo Mandenka17.7
Guinea Bissau15.6
Cameroon Bamileke14.9
Cape Verde Southeastern I…14.8
Cameroon Beti13.5
Zimbabwe Harare Shona12.7
USA African America11.1
Portugal North10.9
South African Natal Zulu10.0
Cuban Mulatto9.5
Tunisia9.4
Kenya Luo8.9
Morocco Berber Nador Meta…8.2
Zambia Lusaka8.1
China Beijing7.5
Kenya Nandi7.1
Uganda Kampala6.8
Georgia Tbilisi Kurds6.7
Portugal South6.1
Sudanese5.8
Bulgaria5.5
Israel Arab Druse5.5
Saudi Arabia Guraiat and …5.4
Spain Catalonia Girona4.6
Kenya4.5
Venezuela Caracus4.0
USA South Texas Hispanics3.9
Mexico Mestizos3.7
Russia Tuva pop 22.9
Romanian2.5
Croatia2.3
Brazil2.0
Spain Basque Gipuzkoa Pro…2.0
Australia New South Wales1.9
Czech Republic1.9
Georgia Tbilisi Georgian…1.9
Oman1.7
Belgium1.6
USA North American Native…1.6
China Inner Mongolia1.5
India New Delhi1.5
Pakistan Pathan1.5
Ireland Northern1.4
Jordan Amman1.4
Mongolia Buriat1.4
Pakistan Sindhi1.3
USA Caucasian (2)1.3
France South East1.2
Italy North Pavia1.2
Iran Baloch1.1
Italy Bergamo1.1
France Corsica1.0
India North Hindus1.0
Portugal Centre1.0
Allele frequencies presented, only

Haplotypes

A23-B7 is found in N.Afr. and S.Afr non-caucasians.
A23-B44 is found in Albania, Zimbabwe, Morocco, Spain and Danes.
A23-B58 is found in the !kung and Zaire.

Associated diseases

A*23:Cw*07 is associated with higher viral load in HIV[4]

References

  1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
  4. Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow R (2002). "Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1". J Virol. 76 (16): 8276–84. doi:10.1128/JVI.76.16.8276-8284.2002. PMC 155130. PMID 12134033.
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