HLA-A31
(MHC Class I, A cell surface antigen)
HLA-A31
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*3101, β2-microglobulin
Older names	A19
Subtypes
Subtype allele Available structures A31 *3101 {{{cNick2}}} *31{{{cAllele2}}} {{{cNick3}}} *31{{{cAllele3}}} {{{cNick4}}} *31{{{cAllele4}}}
Rare alleles
Subtype allele Available structures A31.2 *3102 {{{rnick2}}} *31{{{rallele2}}} {{{rnick3}}} *31{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A31 (A31) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³¹ subset of HLA-A α-chains. For A31, the alpha "A" chain are encoded by the HLA-A*31 allele group and the β-chain are encoded by B2M locus.^[1] This group currently is dominated by A*3101. A31 and A*31 are almost synonymous in meaning. A31 is a split antigen of the broad antigen serotype A19. A31 is a sister serotype of A29, A30, A32, A33, and A74.

A31 is more common in South and Central America.

Serotype

There is substantive false reaction of A30 with A*3101, otherwise serological identification is good.

Distribution

Haplotypes

Examination of A31 haplotypes reveals a probable connection across northern Eurasia during the prehistoric period. Frequencies of the more 'tale-tell' haplotypes (A31-B60, B61, and B62) fall from NE to SW Europe. Other haplotypes appears to have spread from the Middle East (A31-B51 and A31-B35).

References