LGR4

LGR4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KT1, 4QXE, 4QXF
Identifiers
Aliases	LGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4, DPSL
External IDs	OMIM: 606666 MGI: 1891468 HomoloGene: 10226 GeneCards: LGR4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	27,472,790 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	109,844,602 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; hair follicle; ; rectum; ; metanephros; ; metanephric glomerulus; ; germinal epithelium; ; kidney tubule; ; palpebral conjunctiva; ; right uterine tube; ; liver;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; renal corpuscle; ; ciliary body; ; left colon; ; epithelium of stomach; ; kidney; ; ileum; ; urothelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein binding; transmembrane signaling receptor activity; G protein-coupled receptor activity; protein-hormone receptor activity; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane;
Biological process	hair follicle development; G protein-coupled receptor signaling pathway; cell differentiation; positive regulation of branching involved in ureteric bud morphogenesis; male genitalia development; metanephric nephron tubule morphogenesis; rhythmic process; metanephric glomerulus development; immune system process; epithelial cell proliferation; Wnt signaling pathway; tube morphogenesis; positive regulation of transcription, DNA-templated; multicellular organism development; cell differentiation involved in metanephros development; intestinal stem cell homeostasis; epithelial cell proliferation involved in renal tubule morphogenesis; circadian rhythm; canonical Wnt signaling pathway involved in metanephric kidney development; digestive tract development; innate immune response; negative regulation of transcription, DNA-templated; signal transduction; positive regulation of canonical Wnt signaling pathway; bone remodeling; circadian regulation of gene expression; spermatogenesis; osteoblast differentiation; bone mineralization; negative regulation of toll-like receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; hormone-mediated signaling pathway; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55366
	107515
	ENSG00000205213
	ENSMUSG00000050199
	Q9BXB1
	A2ARI4
	NM_018490; NM_001346432
	NM_172671
	NP_001333361; NP_060960
	NP_766259
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.^[5]^[6] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000205213 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050199 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923. S2CID 607389.
↑ "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/me.12.12.1830. PMID 9849958.
Loh ED, Broussard SR, Kolakowski LF (2001). "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor". Biochem. Biophys. Res. Commun. 282 (3): 757–64. doi:10.1006/bbrc.2001.4625. PMID 11401528.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000205213 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050199 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10894923-5] Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923. S2CID 607389.

[entrez-6] "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

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References

Further reading