MIR489
Identifiers
AliasesMIR489, MIRN489, hsa-mir-489, mir-489, microRNA 489
External IDsOMIM: 614523 GeneCards: MIR489
Orthologs
SpeciesHumanMouse
Entrez

574442

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Ensembl

ENSG00000207656

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UniProt

n
a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)Chr 7: 93.48 – 93.48 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. miR-489 acts as tumor suppressor miRNA in breast cancer by inhibiting various oncogenic signaling pathway. It has been demonstrated miR-489 target HER2 and LAPTM4b by directly binding to their 3'UTR. Role of miR-489 has been studied in autochatothus MMTV-Her2 mouse model.[4]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000207656 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: MicroRNA 489".
  4. Patel Y, Shah N, Lee JS, Markoutsa E, Jie C, Liu S, Botbyl R, Reisman D, Xu P, Chen H (April 2016). "A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth". Oncotarget. 7 (14): 18295–308. doi:10.18632/oncotarget.7577. PMC 4951289. PMID 26918448.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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