mir-24 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-24
Identifiers
Symbolmir-24
RfamRF00178
miRBaseMI0000080
miRBase familyMIPF0000041
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

The miR-24 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 is conserved in various species, and is clustered with miR-23 and miR-27, on human chromosome 9 and 19.[1] Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic differentiation [2] and also to promote keratinocyte differentiation by repressing actin-cytoskeleton regulators PAK4, Tsk5 and ArhGAP19.[3]

Targets of miR-24

  • Lal et al. suggested that miR-24 suppresses the tumor suppressor p16(INK4a).[1]
  • Lal et al. reported that mi-24 inhibits cell proliferation by targeting E2F2, MYC via binding to "seedless" 3'UTR microRNA recognition elements.[2]
  • Amelio I. et al. suggest that miR-24 regulates keratinocyte differentiation, controlling actin-cytoskeleton dynamics via PAK4, Tsk5 and ArhGAP19 repression.[3]
  • Wang et al. have shown that miR-24 reduces the mRNA and protein levels of human ALK4 by targeting the 3'-untranslated region of mRNA.[4]
  • Mishra et al. suggest that miR-24 targets the DHFR gene.[5]
  • miR-24-1, also known as miR-189, targets SLITRK1.[6][7]

References

  1. 1 2 Lal A, Kim HH, Abdelmohsen K, et al. (2008). Preiss T (ed.). "p16(INK4a) translation suppressed by miR-24". PLOS ONE. 3 (3): e1864. Bibcode:2008PLoSO...3.1864L. doi:10.1371/journal.pone.0001864. PMC 2274865. PMID 18365017. Open access icon
  2. 1 2 Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J (2009). Preiss T (ed.). "miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements". Molecular Cell. 35 (5): 610–25. doi:10.1016/j.molcel.2009.08.020. PMC 2757794. PMID 19748357.
  3. 1 2 Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G (October 2012). "miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration". The Journal of Cell Biology. 199 (2): 347–63. doi:10.1083/jcb.201203134. PMC 3471232. PMID 23071155.
  4. ↑ Wang Q, Huang Z, Xue H, et al. (January 2008). "MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4". Blood. 111 (2): 588–95. doi:10.1182/blood-2007-05-092718. PMID 17906079.
  5. ↑ Mishra PJ, Humeniuk R, Mishra PJ, Longo-Sorbello GS, Banerjee D, Bertino JR (August 2007). "A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance". Proceedings of the National Academy of Sciences of the United States of America. 104 (33): 13513–8. Bibcode:2007PNAS..10413513M. doi:10.1073/pnas.0706217104. PMC 1948927. PMID 17686970.
  6. ↑ Abelson, J. F.; Benthe, HF; Haberland, G (14 October 2005). "Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome". Science. 310 (5746): 317–320. Bibcode:2005Sci...310..317A. doi:10.1126/science.1116502. PMID 16224024. S2CID 30102870.
  7. ↑ Larsen, K; Momeni, J; Farajzadeh, L; Bendixen, C (2014). "Porcine SLITRK1: Molecular cloning and characterization". FEBS Open Bio. 4: 872–8. doi:10.1016/j.fob.2014.10.001. PMC 4215120. PMID 25379384.


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