MYLK3

MYLK3
Identifiers
Aliases	MYLK3, MLCK, MLCK2, caMLCK, myosin light chain kinase 3
External IDs	OMIM: 612147 MGI: 2443063 HomoloGene: 35278 GeneCards: MYLK3
Gene location (Human)
Chr.	Chromosome 16 (human)
End	46,790,407 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	86,112,974 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; body of tongue; ; thoracic diaphragm; ; triceps brachii muscle; ; vena cava; ; vastus lateralis muscle; ; deltoid muscle; ; glomerulus; ; metanephric glomerulus; ; tibialis anterior muscle;
	Top expressed in
	myocardium of ventricle; ; atrium; ; interventricular septum; ; atrioventricular valve; ; esophagus; ; endocardial cushion; ; left ventricle; ; bone marrow; ; semi-lunar valve; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	calmodulin-dependent protein kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity; ATP binding; myosin light chain kinase activity;
Cellular component	cytoplasm; actin cytoskeleton; cytosol; intracellular anatomical structure;
Biological process	protein phosphorylation; positive regulation of sarcomere organization; regulation of vascular permeability involved in acute inflammatory response; sarcomere organization; cellular response to interleukin-1; phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction; sarcomerogenesis; cardiac myofibril assembly;
	Sources:Amigo / QuickGO
Orthologs
	91807
	213435
	ENSG00000140795
	ENSMUSG00000031698
	Q32MK0
	Q3UIZ8
	NM_001308301; NM_182493
	NM_001297612; NM_175441
	NP_001295230; NP_872299
	NP_001284541; NP_780650
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.^[5]^[6]

Function

Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140795 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031698 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MLCK MLCK protein".
↑ Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. doi:10.1172/JCI30804. PMC 1978424. PMID 17885681.
↑ Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H (March 2008). "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571–80. doi:10.1161/CIRCRESAHA.107.161687. PMC 2504503. PMID 18202317.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Clayburgh DR, Rosen S, Witkowski ED, et al. (2005). "A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability". J. Biol. Chem. 279 (53): 55506–13. doi:10.1074/jbc.M408822200. PMC 1237105. PMID 15507455.
Wang F, Graham WV, Wang Y, et al. (2005). "Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression". Am. J. Pathol. 166 (2): 409–19. doi:10.1016/S0002-9440(10)62264-X. PMC 1237049. PMID 15681825.
Russo JM, Florian P, Shen L, et al. (2005). "Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure". Gastroenterology. 128 (4): 987–1001. doi:10.1053/j.gastro.2005.01.004. PMC 1237051. PMID 15825080.
Shimizu S, Yoshida T, Wakamori M, et al. (2006). "Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells". J. Physiol. 570 (Pt 2): 219–35. doi:10.1113/jphysiol.2005.097998. PMC 1464317. PMID 16284075.
Kim MT, Kim BJ, Lee JH, et al. (2006). "Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells". Am. J. Physiol., Cell Physiol. 290 (4): C1031–40. doi:10.1152/ajpcell.00602.2004. PMID 16306123.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Connell LE, Helfman DM (2007). "Myosin light chain kinase plays a role in the regulation of epithelial cell survival". J. Cell Sci. 119 (Pt 11): 2269–81. doi:10.1242/jcs.02926. PMID 16723733.
Seguchi O, Takashima S, Yamazaki S, et al. (2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. doi:10.1172/JCI30804. PMC 1978424. PMID 17885681.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000140795 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031698 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MLCK MLCK protein".

[pmid17885681-6] Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. doi:10.1172/JCI30804. PMC 1978424. PMID 17885681.

[pmid18202317-7] Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H (March 2008). "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571–80. doi:10.1161/CIRCRESAHA.107.161687. PMC 2504503. PMID 18202317.

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[3]

[4]

[5]

[6]

[7]

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Function

See also

References

Further reading