PFTK1

CDK14
Identifiers
Aliases	CDK14, PFTAIRE1, PFTK1, cyclin-dependent kinase 14, cyclin dependent kinase 14
External IDs	OMIM: 610679 MGI: 894318 HomoloGene: 7888 GeneCards: CDK14
Gene location (Human)
Chr.	Chromosome 7 (human)
End	91,210,590 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	5,470,312 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; Region I of hippocampus proper; ; entorhinal cortex; ; Brodmann area 10; ; superior frontal gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; frontal pole; ; endothelial cell; ; occipital lobe;
	Top expressed in
	cingulate gyrus; ; habenula; ; medial dorsal nucleus; ; amygdala; ; mammillary body; ; dentate gyrus; ; lateral geniculate nucleus; ; pontine nuclei; ; medial geniculate nucleus; ; hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; cyclin binding;
Cellular component	membrane; plasma membrane; cytoplasmic cyclin-dependent protein kinase holoenzyme complex; nucleus; cytoplasm; cytosol;
Biological process	phosphorylation; regulation of canonical Wnt signaling pathway; Wnt signaling pathway; cell division; protein phosphorylation; G2/M transition of mitotic cell cycle; cell cycle; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5218
	18647
	ENSG00000058091
	ENSMUSG00000028926
	O94921
	O35495
	NM_001287135; NM_001287136; NM_001287137; NM_012395
	NM_011074; NM_001310448
	NP_001274064; NP_001274065; NP_001274066; NP_036527
	NP_001297377; NP_035204
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene.^[5]^[6]^[7]

Interactions

PFTK1 has been shown to interact with SEPT8.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000058091 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028926 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem. 69 (1): 348–64. doi:10.1046/j.1471-4159.1997.69010348.x. PMID 9202329. S2CID 41686721.
↑ Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1". Gene. 267 (2): 165–72. doi:10.1016/S0378-1119(01)00391-2. PMID 11313143.
↑ "Entrez Gene: PFTK1 PFTAIRE protein kinase 1".
↑ Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. China. 34 (4): 520–5. ISSN 0582-9879. PMID 12098780.

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Yang T, Gao YK, Chen JY (2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (4): 520–5. PMID 12098780.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Gao Y, Jiang M, Yang T, et al. (2006). "A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins". Cell Res. 16 (6): 539–47. doi:10.1038/sj.cr.7310071. PMID 16775625.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Shu F, Lv S, Qin Y, et al. (2007). "Functional characterization of human PFTK1 as a cyclin-dependent kinase". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9248–53. Bibcode:2007PNAS..104.9248S. doi:10.1073/pnas.0703327104. PMC 1890480. PMID 17517622.
Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000058091 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028926 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9202329-5] Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem. 69 (1): 348–64. doi:10.1046/j.1471-4159.1997.69010348.x. PMID 9202329. S2CID 41686721.

[pmid11313143-6] Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1". Gene. 267 (2): 165–72. doi:10.1016/S0378-1119(01)00391-2. PMID 11313143.

[entrez-7] "Entrez Gene: PFTK1 PFTAIRE protein kinase 1".

[pmid12098780-8] Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. China. 34 (4): 520–5. ISSN 0582-9879. PMID 12098780.

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Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading