PLAG1
Identifiers
AliasesPLAG1, PSA, SGPA, ZNF912, PLAG1 zinc finger, SRS4
External IDsOMIM: 603026 MGI: 1891916 HomoloGene: 1993 GeneCards: PLAG1
Orthologs
SpeciesHumanMouse
Entrez

5324

56711

Ensembl

ENSG00000181690

ENSMUSG00000003282

UniProt

Q6DJT9

Q9QYE0

RefSeq (mRNA)

NM_001114634
NM_001114635
NM_002655

NM_019969

RefSeq (protein)

NP_001108106
NP_001108107
NP_002646

NP_064353

Location (UCSC)Chr 8: 56.16 – 56.21 MbChr 4: 3.9 – 3.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein PLAG1 is a protein that in humans is encoded by the PLAG1 gene.[5][6]

Function

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas.[6]

Interactions

PLAG1 has been shown to interact with Karyopherin alpha 2.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000181690 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003282 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kas K, Röijer E, Voz M, Meyen E, Stenman G, Van de Ven WJ (Nov 1997). "A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands". Genomics. 43 (3): 349–58. doi:10.1006/geno.1997.4819. PMID 9268638.
  6. 1 2 "Entrez Gene: PLAG1 pleiomorphic adenoma gene 1".
  7. Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (May 2002). "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal". J. Biol. Chem. 277 (22): 19673–8. doi:10.1074/jbc.M112112200. PMID 11882654.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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