PRKAA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRKAA1, AMPK, AMPKa1, Protein kinase, AMP-activated, alpha 1, protein kinase AMP-activated catalytic subunit alpha 1
External IDsOMIM: 602739 MGI: 2145955 HomoloGene: 49590 GeneCards: PRKAA1
EC number2.7.11.26
Orthologs
SpeciesHumanMouse
Entrez

5562

105787

Ensembl

ENSG00000132356

ENSMUSG00000050697

UniProt

Q13131

Q5EG47

RefSeq (mRNA)

NM_006251
NM_206907

NM_001013367
NM_001355640

RefSeq (protein)

NP_001013385
NP_001342569

Location (UCSC)Chr 5: 40.76 – 40.8 MbChr 15: 5.17 – 5.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.[5][6]

The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]

Interactions

Protein kinase, AMP-activated, alpha 1 has been shown to interact with TSC2.[7][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132356 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050697 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem. 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660.
  6. 1 2 "Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit".
  7. Inoki, Ken; Zhu Tianqing; Guan Kun-Liang (Nov 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell. United States. 115 (5): 577–90. doi:10.1016/S0092-8674(03)00929-2. ISSN 0092-8674. PMID 14651849. S2CID 18173817.
  8. Shaw, Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell. United States. 6 (1): 91–9. doi:10.1016/j.ccr.2004.06.007. ISSN 1535-6108. PMID 15261145.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)


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