RING1
Identifiers
AliasesRING1, RING1A, RNF1, ring finger protein 1
External IDsOMIM: 602045 MGI: 1101770 HomoloGene: 68283 GeneCards: RING1
Orthologs
SpeciesHumanMouse
Entrez

6015

19763

Ensembl

ENSG00000204227

ENSMUSG00000024325

UniProt

Q06587

O35730

RefSeq (mRNA)

NM_002931

NM_009066

RefSeq (protein)

NP_002922

NP_033092

Location (UCSC)Chr 6: 33.21 – 33.21 MbChr 17: 34.24 – 34.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RING1 is an enzyme that in humans is encoded by the RING1 gene.[5][6]

Function

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.[6]

Interactions

RING1 has been shown to interact with CBX8,[7] BMI1[8][9] and RYBP.[10][11]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000204227 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024325 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hanson IM, Poustka A, Trowsdale J (Jun 1991). "New genes in the class II region of the human major histocompatibility complex". Genomics. 10 (2): 417–24. doi:10.1016/0888-7543(91)90327-B. PMID 1906426.
  6. 1 2 "Entrez Gene: RING1 ring finger protein 1".
  7. Bárdos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". The Journal of Biological Chemistry. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.
  8. Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP (Jul 1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular Biology. 17 (7): 4105–13. doi:10.1128/mcb.17.7.4105. PMC 232264. PMID 9199346.
  9. Satijn DP, Otte AP (Jan 1999). "RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity". Molecular and Cellular Biology. 19 (1): 57–68. doi:10.1128/mcb.19.1.57. PMC 83865. PMID 9858531.
  10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  11. García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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