TSEN2
Identifiers
AliasesTSEN2, PCH2B, SEN2, SEN2L, tRNA splicing endonuclease subunit 2
External IDsOMIM: 608753 MGI: 2141599 HomoloGene: 41622 GeneCards: TSEN2
Orthologs
SpeciesHumanMouse
Entrez

80746

381802

Ensembl

ENSG00000154743

ENSMUSG00000042389

UniProt

Q8NCE0

Q6P7W5

RefSeq (mRNA)

NM_199033

RefSeq (protein)

NP_950198

Location (UCSC)Chr 3: 12.48 – 12.54 MbChr 6: 115.52 – 115.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.[5][6]

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][6]

Interactions

TSEN2 has been shown to interact with TSEN34[5] and TSEN15.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154743 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042389 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.
  6. 1 2 "Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae)".

Further reading


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