TSEN34
Identifiers
AliasesTSEN34, LENG5, PCH2C, SEN34, SEN34L, tRNA splicing endonuclease subunit 34
External IDsOMIM: 608754 MGI: 1913328 HomoloGene: 44182 GeneCards: TSEN34
Orthologs
SpeciesHumanMouse
Entrez

79042

66078

Ensembl

ENSMUSG00000035585

UniProt

Q9BSV6

Q8BMZ5

RefSeq (mRNA)

NM_001077446
NM_001282332
NM_001282333
NM_024075
NM_001386740

NM_001164204
NM_001164205
NM_024168

RefSeq (protein)

NP_001070914
NP_001269261
NP_001269262
NP_076980

NP_001157676
NP_001157677
NP_077130

Location (UCSC)Chr 19: 54.19 – 54.19 MbChr 7: 3.7 – 3.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.[5][6][7]

tRNA splicing is a fundamental process required for cell growth and division. SEN34 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][7]

Interactions

TSEN34 has been shown to interact with TSEN2.[6]

References

  1. 1 2 3 ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 GRCh38: Ensembl release 89: ENSG00000278622, ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035585 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
  6. 1 2 Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.
  7. 1 2 "Entrez Gene: TSEN34 tRNA splicing endonuclease 34 homolog (S. cerevisiae)".

Further reading


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