Operations in Central America, the Galápagos Islands, and the Caribbean

Unimak was tested into late January 1944. When tests were completed, she departed San Diego on 20 March 1944, bound for the Panama Canal Zone. Arriving at Balboa, Panama, on 28 March 1944, Unimak operated on the Pacific coast of Central America into April 1944, providing logistics support to advanced seaplane bases at Santa Elena Bay, Ecuador, and at Aeolian Bay, Baltra Island, in the Galápagos Islands. She soon shifted to Coco Solo on the Caribbean side of the Panama Canal and transported men and materiel to Barranquilla, Colombia, arriving there on 25 April 1944.

After escorting the merchant ship SS Genevieve Lykes back to Coco Solo on 23 and 24 June 1944, Unimak conducted routine exercises with patrol planes into July 1944. On 4 July 1944 she received reports that a tanker near her position had been torpedoed, and headed for the damaged ship. When she arrived on the scene late that day, Unimak found the tanker still underway, making for the Panama coast. She immediately commenced screening the disabled ship and, aided by an escort of United States Army Air Forces and U.S. Navy planes, shepherded the tanker safely to Colón, Panama, late on the afternoon of 5 July 1944.

Soon thereafter, Unimak shaped her course towards the last reported position of the U.S. Navy K-class blimp K-53. At 15:32 hours on 9 July 1944, she sighted two yellow rubber life rafts and the wreckage of the crashed blimp floating on the water. At 15:58 hours, Unimak took on board nine survivors and sank the unsalvageable blimp by collapsing the bag with 40-millimeter gunfire. She then landed the survivors at Portland Bight, Jamaica.

On 13 July 1944, Unimak joined with the destroyer USS John D. Edwards in hunting for a submarine reported to be lurking nearby. Within a few days, word of a crashed plane sent the two ships speeding for the last reported position of the aircraft. When they arrived at the crash site, they found widespread debris and small floating pieces of the crashed plane. It was noted in the ship's diary that they recovered a "mutilated unidentifiable crewmember's body" that was "badly blasted and burned". The aviator was buried at sea with full military honors on 16 July 1944 at 10°14′30″N 078°53′00″W / 10.24167°N 78.88333°W / 10.24167; -78.88333.

Unimak remained in the Caribbean through the autumn of 1944, tending patrol planes, conducting logistics support missions for advanced seaplane bases, and occasionally towing targets for the patrol planes training in the area. On 15 December 1944, the seaplane tender USS Rockaway relieved Unimak, releasing her to steam north via Norfolk, Virginia to Boston.

Voyages to England

Arriving at Boston at the end of December 1944, Unimak underwent availability at the Boston Navy Yard for the entire month of January 1945. She got underway for England on 14 February 1945, but an engineering casualty forced her to return to Boston for a major propeller shaft alignment which lasted into March.

On 7 April 1945, Unimak got underway for the British Isles and proceeded, via Bahia Praia in the Azores, to Bristol, England, on the first of two voyages to England to bring back supplies and men from decommissioned U.S. Navy patrol plane squadrons in the United Kingdom, and was engaged in these activities when WWII ended in May 1945. On the second voyage, from 5 June 1945 to 15 June 1945, Unimak transported the men and material of Patrol Bomber Squadron 103 (VPB-103 and 105) from Bristol to Norfolk.

Transfer to the Pacific

Departing Hampton Roads, Virginia, on 20 July 1945, bound for the United States West Coast, Unimak transited the Panama Canal on 26 July 1945 and arrived at San Diego on 3 August 1945. She got underway for Pearl Harbor, Hawaii on 12 August 1945. She was en route when hostilities with Japan ended on 15 August 1945 bringing World War II to a close.

1949–1975

Unimak was home-ported in Boston, Massachusetts, from 3 January 1949 to 1 September 1956. Her primary duty during her Coast Guard service was to serve on ocean stations to gather meteorological data. While on duty in one of these stations, she was required to patrol a 210-square-mile (544-square-kilometer) area for three weeks at a time, leaving the area only when physically relieved by another Coast Guard cutter or in the case of a dire emergency. While on station, she acted as an aircraft check point at the point of no return, a relay point for messages from ships and aircraft, as a source of the latest weather information for passing aircraft, as a floating oceanographic laboratory, and as a search-and-rescue ship for downed aircraft and vessels in distress. She also engaged in law enforcement operations.

In June 1956, Unimak patrolled the Newport, Rhode Island-to-Bermuda race.

Unimak was stationed at Cape May, New Jersey, from 1 September 1956 to 7 August 1972 and used primarily for training United States Coast Guard Reserve personnel, including training cruises to Brazil and Nova Scotia. She took part in the United States Coast Guard Academy cadet cruise of August 1965.

Unimak was reclassified as a high endurance cutter and redesignated WHEC-379 on 1 May 1966. Her loan period from the Navy came to an end on 26 September 1966, when she was transferred permanently from the Navy to the Coast Guard.

On 7 March 1967, Unimak rescued six Cuban refugees in the Yucatán Channel. On 10 March 1967 she rescued survivors from the fishing vessel Bunkie III in Florida waters. On 15 March 1967, she rescued 12 Cuban refugees who were stranded on an island. On 29 May 1969, she towed the fishing vessel Sirocco–which was disabled 35 nautical miles (65 km) east of Fort Pierce, Florida–to safety.

Unimak was reclassified as a training ship and again redesignated, this time as WTR-379, on 28 November 1969. On 3 April 1970, she stood by the grounded merchant ship Vassiliki near Mayaguana Island until a commercial tugboat arrived to assist Vassiliki.

From 7 August 1972 to 31 May 1975, Unimak was stationed at Yorktown, Virginia, and was again used to train Coast Guard reservists.

The Coast Guard decommissioned Unimak on 31 May 1975 and placed her in reserve at the Coast Guard Yard at Curtis Bay, Maryland.

1977–1988

On 22 August 1977, the Coast Guard recommissioned Unimak, reclassifying her as a high-endurance cutter and returning her to the designation WHEC-379. She was home-ported at New Bedford, Massachusetts, for the rest of her Coast Guard career. During this stint in commission, she was used primarily for fisheries patrol in the Atlantic, law enforcement operations in the Caribbean and as a weather ship for the United States International Weather Patrol.

Unimak also interdicted the trafficking of illegal drugs. On 6 October 1980, she seized the merchant ship Janeth 340 nautical miles (630 km) southeast of Miami; Janeth was carrying 500 bales of marijuana. On 14 October 1980, she seized the pleasure craft Rescue, which was carrying approximately 500 bales of marijuana, and the pleasure craft Snail, with two tons of marijuana on board, in the Gulf of Mexico. On 17 October 1980, she seized the merchant vessel Amalaka southwest of Key West, Florida; Amalaka was carrying 1,000 bales of marijuana. On 19 October 1980, she seized the fishing vessel Wright's Pride southwest of Key West; the ship had 30 tons of marijuana aboard. In March 1981, while on an Officer Candidate School training cruise, she intercepted the merchant ship Mayo with 40 tons of marijuana on board.

On 9 October 1982,^{[lower-alpha 1]} Unimak towed the disabled fishing vessel Sacred Heart away from Daid Banks, 45 nautical miles (83 km; 52 mi) east of Cape Cod, Massachusetts, in 30-foot (9.1 m) seas.^[1]

Between 28 January 1983 and 9 March 1983, Unimak again deployed to the Caribbean for a law-enforcement patrol. On 27 and 28 February 1983, she towed the dismasted sailing vessel Wandering Star to Matthew Town on Great Inagua in the Bahamas. On 3 March 1983, she towed the disabled merchant vessel Yadrina to Matthew Town.

On 30 November 1984, Unimak seized the sailboat Lola 100 nautical miles (190 km; 120 mi) north of Barranquilla; Lola had 1.5 tons of marijuana on board. Another drug seizure occurred on 2 November 1985, when Unimak seized the tug Zeus 3 and a barge 200 nautical miles (370 km; 230 mi) south of the Dominican Republic; the two vessels were carrying 40 tons of marijuana.