Juniors

As a junior Malisse compiled a singles win–loss record of 66–18, reaching as high as No. 10 in the junior world singles rankings in 1997. He made the quarterfinals of Wimbledon in 1997, whilst his final junior tournament was winning Eddie Herr later that year.

1998–2008

Malisse turned professional in 1998.

His best performance in Grand Slam singles competition was at the 2002 Wimbledon championships, where he reached the semi-final, beating Galo Blanco, Vince Spadea, Yevgeny Kafelnikov and Britain's Greg Rusedski in five sets en route, as well as former champion Richard Krajicek. He eventually lost to runner-up David Nalbandian, again in five sets. Malisse and Olivier Rochus won the French Open doubles championship in 2004. He has won three ATP tour singles titles: Delray Beach in 2005 and 2007, and Chennai in 2007.

2009

After a difficult year, Malisse found himself with a world ranking of 205. In his first tournament of the year in Brisbane, he lost in the last qualifying round to American Bobby Reynolds. A week later, in Medibank International Sydney, he reached the main draw, but lost to Mario Ančić in the first round.

At the Australian Open, he first won his qualifying matches. In the first round of the main draw, he defeated Michaël Llodra. However, in the next round, he lost to Andy Roddick in four sets. In October, he won a Challenger tournament in Lyon, and this pushed him back into the world's top 100 for the first time in nearly two years.

He was banned for a year over doping allegations.^[1][2]

2010

Malisse lost in the third round of Wimbledon to Sam Querrey in five sets.

2011

Xavier started the 2011 season by reaching the final of Chennai. In March, he won the doubles title in the Indian Wells Masters with Alexandr Dolgopolov of Ukraine. He reached the fourth round at Wimbledon, where he lost to Bernard Tomic.

2012

Xavier reached the fourth round of Wimbledon where he faced Roger Federer. Federer won the first two sets and went a break up in the third, but Malisse came back to win the third set and move 2–0 in the fourth. Federer subsequently won six out of the next seven games to win the match and went on to win the Title.

2016–2018

After retiring in 2013 and competing in an ITF doubles event in 2015, Malisse entered the 2016 Meerbusch Challenger in doubles, ultimately conceding a walkover to end his playing career. He then participated in the ATP Champions Tour until 2018.

2021–2022

Malisse came out of retirement to play doubles at the 2021 European Open having received a wildcard alongside Lloyd Harris whom he was coaching.^[3] The pair made the semifinals defeating top seeds Ivan Dodig and Marcelo Melo en route before losing to 3rd seeds Jean-Julien Rojer and Wesley Koolhof in straight sets.

He also participated in the 2022 European Open having received again a wildcard to play doubles with Diego Schwartzman. In the first round they managed to beat Raven Klaasen and Marcelo Melo in straight sets.^[4] In the quarterfinals, they lost to Botic van de Zandschulp and Tallon Griekspoor in two tie-breaks.^[5]

Grand Slam finals

Doubles: 1 (1–0)

Result	Year	Championship	Surface	Partner	Opponents	Score
Win	2004	French Open	Clay	Olivier Rochus	Michaël Llodra Fabrice Santoro	7–5, 7–5

Masters 1000 finals

Doubles: 1 (1–0)

Result	Year	Tournament	Surface	Partner	Opponents	Score
Win	2011	Indian Wells	Hard	Alexandr Dolgopolov	Roger Federer Stan Wawrinka	6–4, 6–7(5–7), [10–7]

Singles: 12 (3 titles, 9 runners-up)

Result	W–L	Date	Tournament	Tier	Surface	Opponent	Score
Loss	0–1	Nov 1998	Mexican Open, Mexico	World Series	Clay	Jiří Novák	3–6, 3–6
Loss	0–2	May 1999	Delray Beach ITC, US	World Series	Clay	Lleyton Hewitt	4–6, 7–6(7–2), 1–6
Loss	0–3	Mar 2001	Delray Beach ITC, US	International	Hard	Jan-Michael Gambill	5–7, 4–6
Loss	0–4	Apr 2001	Atlanta Tennis Challenge, US	International	Clay	Andy Roddick	2–6, 4–6
Loss	0–5	May 2004	St. Pölten Open, Austria	International	Clay	Filippo Volandri	1–6, 4–6
Loss	0–6	Oct 2004	Grand Prix de Tennis de Lyon, France	International	Carpet (i)	Robin Söderling	2–6, 6–3, 4–6
Win	1–6	Jan 2005	Delray Beach ITC, US	International	Hard	Jiří Novák	7–6(8–6), 6–2
Loss	1–7	Jan 2006	Adelaide International, Australia	International	Hard	Florent Serra	3–6, 4–6
Loss	1–8	Feb 2006	Delray Beach ITC, US	International	Hard	Tommy Haas	3–6, 6–3, 6–7(5–7)
Win	2–8	Jan 2007	Chennai Open, India	International	Hard	Stefan Koubek	6–1, 6–3
Win	3–8	Feb 2007	Delray Beach ITC, US (2)	International	Hard	James Blake	5–7, 6–4, 6–4
Loss	3–9	Jan 2011	Chennai Open, India	250 Series	Hard	Stanislas Wawrinka	5–7, 6–4, 1–6

Doubles: 13 (9 titles, 4 runners-up)

Result	W–L	Date	Tournament	Tier	Surface	Partner	Opponents	Score
Win	1–0	Jun 2004	French Open, France	Grand Slam	Clay	Olivier Rochus	Michaël Llodra Fabrice Santoro	7–5, 7–5
Win	2–0	Jan 2006	Adelaide International, Australia	International	Hard	Olivier Rochus	Simon Aspelin Todd Perry	7–6(7–5), 6–4
Win	3–0	Jan 2007	Chennai Open, India	International	Hard	Dick Norman	Rafael Nadal Bartolomé Salvá Vidal	7–6(7–4), 7–6(7–4)
Win	4–0	Feb 2007	Delray Beach ITC, US	International	Hard	Hugo Armando	James Auckland Stephen Huss	6–3, 6–7(4–7), [10–5]
Loss	4–1	Jan 2008	Auckland Open, New Zealand	International	Hard	Jürgen Melzer	Luis Horna Juan Mónaco	4–6, 6–3, [7–10]
Loss	4–2	Feb 2011	Pacific Coast Championships, US	250 Series	Hard (i)	Alejandro Falla	Scott Lipsky Rajeev Ram	4–6, 6–4, [8–10]
Win	5–2	Mar 2011	Indian Wells Masters, US	Masters 1000	Hard	Alexandr Dolgopolov	Roger Federer Stanislas Wawrinka	6–4, 6–7(5–7), [10–7]
Win	6–2	Jul 2011	Los Angeles Open, US	250 Series	Hard	Mark Knowles	Somdev Devvarman Treat Huey	7–6(7–3), 7–6(12–10)
Win	7–2	Feb 2012	Pacific Coast Championships, US	250 Series	Hard (i)	Mark Knowles	Kevin Anderson Frank Moser	6–4, 1–6, [10–5]
Loss	7–3	May 2012	Bavarian Championships, Germany	250 Series	Clay	Dick Norman	František Čermák Filip Polášek	4–6, 5–7
Loss	7–4	Jul 2012	Atlanta Open, US	250 Series	Hard	Michael Russell	Matthew Ebden Ryan Harrison	3–6, 6–3, [6–10]
Win	8–4	Jul 2012	Los Angeles Open, US (2)	250 Series	Hard	Ruben Bemelmans	Jamie Delgado Ken Skupski	7–6(7–5), 4–6, [10–7]
Win	9–4	Feb 2013	Pacific Coast Championships, US (2)	250 Series	Hard (i)	Frank Moser	Lleyton Hewitt Marinko Matosevic	6–0, 6–7(5–7), [10–4]

Singles: 7 (4–3)

Result	W–L	Date	Tournament	Tier	Surface	Opponent	Score
Win	1–0	Oct 2000	San Antonio, United States	Challenger	Hard	Ronald Agénor	7–6(7–3), 6–3
Loss	1–1	Oct 2005	Mons, Belgium	Challenger	Hard	Olivier Rochus	2–6, 0–6
Win	2–1	Jul 2008	Moncton, Canada	Challenger	Hard	Danai Udomchoke	6–4, 6–4
Win	3–1	Aug 2009	Granby, Canada	Challenger	Hard	Kevin Anderson	6–4, 6–4
Loss	3–2	Aug 2009	Vancouver, Canada	Challenger	Hard	Marcos Baghdatis	4–6, 4–6
Loss	3–3	Sep 2009	St. Remy, France	Challenger	Hard	Marcos Baghdatis	4–6, 1–6
Win	4–3	Oct 2009	Orleans, France	Challenger	Hard	Stéphane Robert	6–1, 6–2

Doubles: 4 (2–2)

Result	W–L	Date	Tournament	Tier	Surface	Partner	Opponents	Score
Loss	0–1	Jul 1999	Ostend, Belgium	Challenger	Clay	Wim Neefs	Marcos Ondruska Steven Randjelovic	2–6, 4–6
Win	1–1	Jul 2008	Bogotá, Colombia	Challenger	Clay	Carlos Salamanca	Juan Sebastián Cabal Michael Quintero	6–1, 6–4
Win	2–1	Sep 2008	Donetsk, Ukraine	Challenger	Hard	Dick Norman	Harel Levy Noam Okun	4–6, 6–1, [13–11]
Loss	2–2	Sep 2012	Orleans, France	Challenger	Hard	Ken Skupski	Lukáš Dlouhý Gilles Müller	2–6, 7–6(7–5), [7–10]

Singles

Doubles