PHTPP
Identifiers
  • 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H11F6N3O
Molar mass423.318 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F
  • InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H
  • Key:AEZPAUSGTAHLOQ-UHFFFAOYSA-N

PHTPP is a synthetic, nonsteroidal, and highly selective antagonist of ERβ that is used in scientific research to study the function of this receptor.[1][2] It possesses 36-fold selectivity for ERβ over ERα, and is a silent antagonist of ERβ.[3]

See also

References

  1. ↑ Neurosteroids. Frontiers E-books. pp. 95–. ISBN 978-2-88919-078-2.
  2. ↑ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9.
  3. ↑ Compton DR, Sheng S, Carlson KE, Rebacz NA, Lee IY, Katzenellenbogen BS, Katzenellenbogen JA (November 2004). "Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity". Journal of Medicinal Chemistry. 47 (24): 5872–93. doi:10.1021/jm049631k. PMID 15537344.
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